Base Excision DNA Repair in Plants: Arabidopsis and Beyond
Abstract
:1. Introduction: BER Essentials
2. DNA Damage Specifics in Plants
3. Plant DNA Glycosylases: The Universal Themes
3.1. Uracil–DNA Glycosylases
3.2. Oxidative Damage Repair
4. Epigenetic Glycosylases, the Plants’ Unique Toolkit
5. Unexplained Diversity of Alkylation Damage Glycosylases
6. AP Site Cleavage and 3′-End Processing
7. Downstream Events in Plant BER
7.1. DNA Polymerases
7.2. Flap Endonuclease
7.3. DNA Ligases
7.4. XRCC1
7.5. Poly(ADP-Ribose) Polymerases
8. BER in Plant Mitochondria and Chloroplasts
9. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Enzyme | E. coli | Human | A. thaliana |
---|---|---|---|
Uracil–DNA glycosylases | Ung | UNG | At3g18630 (AtUNG) |
Mug | TDG | ||
SMUG1 | |||
Endonuclease III | Nth | NTHL1 | At2g31450 (AtNTH1) |
At1g05900 (AtNTH2) | |||
A:oxoG-specific adenine–DNA glycosylase | MutY | MUTYH | At4g12740 (AtMYH) |
8-oxoguanine–DNA glycosylase | – | OGG1 | At1g21710 (AtOGG1) |
Bacterial alkylpurine–DNA glycosylase I | Tag | – | At1g13635 |
At1g15970 | |||
At1g75090 | |||
At1g80850 | |||
At3g12710 | |||
At5g44680 | |||
At5g57970 | |||
Bacterial alkylpurine–DNA glycosylase II | AlkA | – | At1g19480 |
At1g75230 | |||
At3g50880 | |||
Human alkylpurine–DNA glycosylase | – | MPG | At3g12040 (AtMAG) |
Methyl-CpG-specific uracil–DNA glycosylase | – | MBD4 | At3g07930 (AtMBD4) |
Formamidopyrimidine–DNA glycosylase/endonuclease VIII | Fpg | At3g07930 (AtMMH) | |
Nei | NEIL1 | ||
NEIL2 | |||
NEIL3 | |||
Epigenetic 5-methylcytosine–DNA glycosylases | – | – | At5g04560 (AtDME) |
At2g36490 (AtROS1) | |||
At3g10010 (AtDML2) | |||
At4g34060 (AtDML3) | |||
At3g47830 | |||
AP endonucleases, EEP superfamily | Xth | APE1 | At2g41460 (AtARP) |
At3g48425 (AtAPE1L) | |||
APE2 | At4g36050 (AtAPE2) | ||
AP endonucleases, TIM barrel superfamily | Nfo | – | – |
3′-phosphatase | – | PNKP | At3g14890 (AtZDP) |
DNA polymerases, Family A | PolI | POLγ | At1g50840 (AtPolIA) |
At3g20540 (AtPolIB) | |||
DNA polymerases, Family X | – | POLβ | |
POLλ | At1g10520 (AtPOLλ) | ||
Flap endonuclease | PolI | FEN1 | At5g26680 (AtFEN1) |
DNA ligase | LigA | Lig I | At1g08130 (AtLIG1) |
At1g49250 | |||
Lig IIIα | |||
BRCT domain scaffold protein | – | XRCC1 | At1g80420 (AtXRCC1) |
Poly(ADP-ribose) polymerases | – | PARP1 | At2g31320 (AtPARP1) |
PARP2 | At4g02390 (AtPARP2) | ||
PARP3 | At5g22470 (AtPARP3) |
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Grin, I.R.; Petrova, D.V.; Endutkin, A.V.; Ma, C.; Yu, B.; Li, H.; Zharkov, D.O. Base Excision DNA Repair in Plants: Arabidopsis and Beyond. Int. J. Mol. Sci. 2023, 24, 14746. https://doi.org/10.3390/ijms241914746
Grin IR, Petrova DV, Endutkin AV, Ma C, Yu B, Li H, Zharkov DO. Base Excision DNA Repair in Plants: Arabidopsis and Beyond. International Journal of Molecular Sciences. 2023; 24(19):14746. https://doi.org/10.3390/ijms241914746
Chicago/Turabian StyleGrin, Inga R., Daria V. Petrova, Anton V. Endutkin, Chunquan Ma, Bing Yu, Haiying Li, and Dmitry O. Zharkov. 2023. "Base Excision DNA Repair in Plants: Arabidopsis and Beyond" International Journal of Molecular Sciences 24, no. 19: 14746. https://doi.org/10.3390/ijms241914746