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Flurbiprofen Derivatives as Potential DPPH and ABTS Radical Scavengers

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Abstract

Flurbiprofen derivatives 1–18 were screened for their free radical scavenging activities. Initially, flurbiprofen hydrazide 1 was synthesized and subjected to various chemical transformations to obtain a range of flurbiprofen hydrazide analogs 2–9 and flurbiprofen–oxadiazole analogs 10–18. All compounds 1–18 showed good DPPH (IC50 = 0.60±0.16 to 1.77±0.04 µM) and ABTS (IC50 = 0.40±0.10 to 1.46±0.06 µM) radical scavenging activities as compared to the standard ascorbic acid (IC50 = 0.51±0.18 µM for both DPPH and ABTS). Among the synthesized derivatives, compound 13 (DPPH, IC50 = 0.40±0.10 µM; ABTS, IC50 = 0.60±0.16 µM) was found to be the most active. The remaining compounds displayed good to moderate radical scavenging activities. These active compounds can serve as lead molecules to identify more powerful antioxidant agents.

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CONFLICT OF INTEREST

The authors declare no conflict of interest.

Notes

  1. Hereinafter, the first value refers to ABTS, and the second, to DPPH scavenging activity.

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Funding

The authors acknowledge the financial support of the Sindh Higher Education Commission (SHEC, Pakistan, letter no. NO.DD/SHEC/1-14/2014, project code SHEC/SRSP/Med-3/15/2021-2).

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Authors and Affiliations

  1. Department of Chemistry, Abdul Wali Khan University, 23200, Mardan, Pakistan

    M. Khan & A. Alam

  2. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Karachi, Pakistan

    U. Salar

  3. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, 52571, Buraydah, Saudi Arabia

    S. Chigurupati

  4. H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, 75270, Karachi, Pakistan

    F. Saleem, S. Hameed & Kh. M. Khan

  5. Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, 31441, Dammam, Saudi Arabia

    M. Taha & Kh. M. Khan

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  1. M. Khan
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Correspondence to Kh. M. Khan.

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Khan, M., Alam, A., Salar, U. et al. Flurbiprofen Derivatives as Potential DPPH and ABTS Radical Scavengers. Russ J Org Chem 59, 1577–1582 (2023). https://doi.org/10.1134/S1070428023090154

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  • DOI: https://doi.org/10.1134/S1070428023090154

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