Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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A Method and Effect for Tibial Defect Treatment Using Interstitial Low Level Laser

경골 손상 치료에서의 침습형 저출력 레이저 치료법 및 효과

  • Lee, Sangyeob (Department of Biomedical Engineering, Yonsei University) ;
  • Hwang, Donghyun (Department of Biomedical Engineering, Yonsei University) ;
  • Kim, Hansung (Department of Biomedical Engineering, Yonsei University) ;
  • Jung, Byungjo (Department of Biomedical Engineering, Yonsei University)
  • Received : 2016.07.22
  • Accepted : 2016.08.23
  • Published : 2016.08.31
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Abstract

Tibial defect, or fracture is very routine musculoskeletal case which brings fully uncomfortable and painful situations to patient. Moreover, it has long hospitalization period because of its risk of non-union. There are many studies using ultrasound, vibration, and laser for bone regeneration to figure out fast bone healing. Among them, Low Level Laser Therapy (LLLT) is already known that it is very easy to treat and may have positive effect for bone regeneration. However, LLLT has uncertain energy dose because of scattering and absorption of laser in tissue. In this study, we used interstitial LLLT to treat tibial defect in animal study. The Interstitial LLLT can overcome some limitations caused by laser scattering or absorption in tissue medium. The results were evaluated using u-CT which can calculate X-ray attenuation coefficient and bone volume of bone defect area. These results showed that interstitial LLLT may affect fast bone healing process in early phase.

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References

  1. Schuit S.C.E., van der Klift M., Weel A.E.A.M., Laet C.E.D.H., Burger H., Seeman E., Hofman A., Uitterlinden A.G., van Leeuwen J.P.T.M. and Pols H.A.P., "Fracture incidence and association with bone mineral density in elderly men and woman: the Rotterdam Study," Bone, vol. 34, no. 1, pp. 195-202, 2004. https://doi.org/10.1016/j.bone.2003.10.001
  2. Antonova E., Le T.K., Burge R. and Mershon J., "Tibia shaft fractures: costly burden of nonunions," BMC Musculoskeletal Disorders, vol. 14, no. 1, pp. 1, 2013. https://doi.org/10.1186/1471-2474-14-1
  3. Michael R.H. and Tatiana N.D., "Mechanisms of low level light therapy," in Proc. SPIE 6140, San Francisco, US, 2006, 614001.
  4. Alghamdi K.M., Kumer A. and Moussa N.A., "Low-level laser therapy: a useful technique for enhancing the proliferation of various cultured cells," Lasers Med. Sci., vol. 27, no. 1, pp. 237-249, 2012. https://doi.org/10.1007/s10103-011-0885-2
  5. J.C. Ahn and P.S. Jung, "Bio-stimulation using low level light" in Proc. COOC 2015, Busan, Korea, May. 2015, pp. 127.
  6. Bjordal J.M., Johnson M.I., Iversen V., Aimbire F. and Lopes-Martins R.A., "Low-Level Laser Therapy in Acute Pain: A Systematic Review of Possible Mechanisms of Action and Clinical Effects in Randomized Placebo-Controlled Trials," Photomedicine and Laser Surgery, vol. 24, no. 2, pp. 158-168, 2006. https://doi.org/10.1089/pho.2006.24.158
  7. Avci P., Gupta A., Sadasivam M., Vecchio D., Pam Z., Pam N., Hamblin M.R., "Low-Level Laser (Light) Therapy (LLLT) in Skin: Stimulating, Healing, Restoring," Seminars in Cutaneous Medicine and Surgery, vol. 32, no. 1, pp. 41-52, 2013.
  8. Bjordal J.M., Couppe C., Chow R.T., Tuner J. and Ljunggren E.A., "A systematic review of low level laser therapy with location-specific doses for pain from joint disorders," Australian Journal of Physiotherapy, vol. 49, no. 2, pp. 107-116, 2003. https://doi.org/10.1016/S0004-9514(14)60127-6
  9. H.S. Kang, C.Y. Ko, Y. Ryu, D.H. Seo, H.S. Kim and B.J. Jung, "Development of a minimally invasive laser needle system: Effects on cortical bone of osteoporotic mice," Lasers Med. Sci., vol. 27, no. 5, pp. 965-969, 2012. https://doi.org/10.1007/s10103-011-1014-y
  10. Tim C.R., Pinto K.N., Rossi B.R., Fernandes K., Matsumoto M.A, Parizotto N.A. and Renno A.C., "Low-level laser therapy enhances the expression of osteogenic factors during bone repair in rats," Lasers Med Sci, vol. 29, no. 1, pp. 147-156, 2013. https://doi.org/10.1007/s10103-013-1302-9
  11. Ozawa Y., Shimizu N., Kariya G., Abiko Y., "Low-Energy Laser Irradiation Stimulates Bone Nodule Formation at Early Stages of Cell Culture in Rat Calvarial Cells," Bone, vol. 22. no. 4, pp. 347-354, 1998.
  12. Tseng S.H., Bargo P., Durkin A. and Kollias N., "Chromophore concentrations, absorption and scattering properties of human skin in-vivo," Opt. Express, vol. 17, no. 17, pp. 14599-14617, 2009. https://doi.org/10.1364/OE.17.014599
  13. Cullum I.D., Ell P.J. and Ryder J.P., "X-ray dual-photon absorptiometry: a new method for the measurement of bone density," Br. J. Radiol., vol. 62, no. 739, pp. 587-592, 1988. https://doi.org/10.1259/0007-1285-62-739-587
  14. Y.M. Yoo, M.H. Lee, J.H. Park, D.H. Seo, S.Y. Lee, B.J. Jung, H.S. Kim and K.H. Bae, "Decreased Bone Volume and Bone Mineral Density in the Tibial Trabecular Bone Is Associated with Per2 Gene by 405 nm Laser Stimulation," Int. J. Mol. Sci., vol. 16, no. 11, pp. 27401-27410, 2015. https://doi.org/10.3390/ijms161126028
  15. S.Y. Lee, M.J. Ha, D.H. Hwang, S.K. Yu, S.K. Jang, J.H. Park, Radfar E., H.S. Kim and B.J. Jung, "Effect of interstitial low level laser therapy on tibial defect" in Proc. SPIE Photonics West, San Francisco, US, 2016, 96950D.