Preparation of composite powders with uniform dispersion, high sphericity, suitable particle size and distribution is a great concern in fabricating high-performance components via additive manufacturing. Herein, we developed a novel technology, namely freeze-dry pulsated orifice ejection method（FD-POEM）, to prepare monodispersed spherical particles. Taking ZrO 2 nano-powders as an example, high-concentration slurries with homogeneous dispersion were prepared. The influence of slurry concentrations or dispersant types on the dispersion behavior of slurry and the properties of FD-POEM particles was thoro ughly investigated. This work demonstrates the great potential of FD-POEM as a promising method to fabricate monodispersed spherical composite powders.