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化学进展 2023, Vol. 35 Issue (9): 1304-1312 DOI: 10.7536/PC230213 前一篇   后一篇

• 综述 •

聚合物水凝胶材料的透氧性能

金诗萍, 孙莹, 张雪勤*()   

  1. 东南大学化学化工学院 南京 211189
  • 收稿日期:2023-02-14 修回日期:2023-06-07 出版日期:2023-09-24 发布日期:2023-08-06
  • 作者简介:

    张雪勤 博士,东南大学化学化工学院副教授,硕士生导师。主要研究方向为高透氧聚合物水凝胶的设计及应用、聚合物光电功能材料的合成及光电子器件。主持和参与国家“863”高技术项目、国家自然科学基金、江苏省自然科学基金、江苏省产学研前瞻性联合项目等多项研究,已在国内外高水平科学杂志上发表论文三十余篇,获得授权发明专利十余项。

  • 基金资助:
    国家自然科学基金面上项目(22275035); 江苏省重点研发计划(No.BE 2022025-2)(BE 2022025-2)
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Oxygen Permeability of Polymer Hydrogel Materials

Shiping Jin, Ying Sun, Xueqin Zhang()   

  1. College of Chemistry and Chemical Engineering, Southeast University,Nanjing 211189, China
  • Received:2023-02-14 Revised:2023-06-07 Online:2023-09-24 Published:2023-08-06
  • Contact: *e-mail: xqzhang@seu.edu.cn
  • Supported by:
    The National Natural Science Foundation of China(22275035); Jiangsu Key Research and Development Program(BE 2022025-2)

近年来,水凝胶在角膜接触镜和医用敷料等生物医学领域得到广泛应用。在这些领域中,透氧性能是衡量水凝胶材料应用性能的关键性指标。本文概述了传统聚合物水凝胶和硅水凝胶在角膜接触镜和医用敷料领域的应用,分别总结了传统水凝胶和硅水凝胶在结构设计及透氧机理方面的研究进展,重点分析了影响硅水凝胶透氧性能的各种因素。希望通过对近期相关研究工作的总结和梳理,能更加深入地理解水凝胶微观结构与透氧性能之间的关系,为调控材料性能和设计出满足需求的材料提供帮助。

关键词： 聚合物水凝胶, 硅水凝胶, 透氧性能, 透氧机理, 微观结构

In recent years, hydrogels have been widely used in biomedical fields such as contact lenses and medical dressings. In these fields, oxygen permeability is a key index to evaluate the application performance of hydrogel materials. In this paper, the application of traditional hydrogels and silicone hydrogels in the field of corneal contact lenses and medical dressings is sketched. The research progress of traditional hydrogels and silicone hydrogels in structural design and oxygen permeability mechanism is summarized, and various factors affecting the oxygen permeability of silicone hydrogels are analyzed emphatically. It is hoped that the relationship between hydrogel microstructure and oxygen permeability can be further understood by summarizing and sorting out the recent related research work, so as to provide help for the regulation of material properties and the design of materials to meet the requirements.

Contents

1 Introduction

2 Progress in oxygen permeability of traditional hydrogels

2.1 Research progress of traditional hydrogels as contact lenses

2.2 Oxygen permeability mechanism of hydrogel materials

3 Progress in oxygen permeability of silicone hydrogels

3.1 Research progress of silicone hydrogels as contact lenses

3.2 Oxygen permeability mechanism of silicone hydrogel materials

4 Conclusion and outlook

Key words: polymer hydrogel, silicone hydrogel, oxygen permeability, oxygen permeability mechanism, microstructure
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图1 水凝胶的Dk与平衡含水率之间的关系[31]
Fig.1 Relationship between Dk of hydrogel and water content[31]
表1 传统水凝胶和硅水凝胶研究工作总结
Table 1 Summary of the work of traditional hydrogels and silicone hydrogels
Component Preparation method Oxygen permeability Water content ref
Traditional hydrogels HEMA、MPC Copolymerization 33 barrer 58% 17
HEMA、MA、MMA Ontology aggregation 35 barrer 45% 23
NVP、HEMA Copolymerization 35 barrer 84.5% 19
Silicone hydrogels KH570、HEMA、NVP Ontology aggregation 35 barrer / 43
SIGMA、HEMA、NVP Hydrate after
copolymerization		 34.5 barrer / 44
PDMS、PEGMA、HEMA Copolymerization 92 barrer / 48
PDMS、PTMO、HMDI Copolymerization 100 barrer / 49
PEG、PDMS Copolymerization 110 barrer / 18
PDMS、PEG、 Fluorohydrocarbon groups Copolymerization 196 barrer / 50
TEOS、PDMS、HEMA、NVP Photopolymerization 71 barrer 73% 52
图2 含水率为37 wt%的HEMA基水凝胶和硅水凝胶的微观形貌模型[58]
Fig.2 Appearance of bulk material (grey) and open spaces (white) in the molecular structure of simulated pHEMA-based material (left) and Si-Hy material (right) at 37 wt% water content[58]. Copyright 2014, Elsevier
图3 Dk与硅含量和分布关系及硅水凝胶的可能形态[62]
Fig.3 The relationship between Dk and silicon content and distribution and the possible forms of silica hydrogels[62]. Copyright 2017, Elsevier
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摘要

聚合物水凝胶材料的透氧性能