关键词: 高频超声参数, 软骨表面的反射系数, 软骨的表面粗糙度系数, 软骨厚度, 基质金属蛋白酶1, 骨γ-羧基谷氨酸蛋白

Abstract: This study investigated the diagnostic value of high frequency ultrasound parameters combined with bone-γ-carboxyglutamic acid-containing protein (BGP) and matrix metalloproteinase 1 (MMP-1) on knee cartilage injury after exercise, and analyzed its correlation with ultrasound parameters, BGP and MMP-1. 88 patients suspected of postmotor knee cartilage injury were selected as the study subjects. 56 patients who were eventually diagnosed with postmotor knee cartilage injury were set to the observation group, and the remaining 32 patients were set to the control group. All patients underwent high-frequency ultrasound examination and compared the surface roughness coefficient (URI), reflection coefficient (RC) of cartilage surface and cartilage thickness in ultrasound parameters between the two groups. Compared with the control group, the observation group had higher URI index (P<0.05), and lower RC and thickness indexes (P<0.05). Compared with RC, URI and cartilage thickness single diagnosis, the combined diagnosis was more effective in the diagnosis of knee cartilage injury after exercise, and the AUC was 0.822 (P<0.05). RC and cartilage thickness were positively correlated with BGP and MMP-1 (P<0.05). URI was negatively correlated with BGP and MMP-1 (P<0.05). Combined diagnosis of high-frequency ultrasound parameters can effectively determine the cartilage tissue damage of the knee joint after exercise, and its parameters were also related to BGP and MMP-1.

Key words: high-frequency ultrasonic parameters, ultrasound roughness index, reflection coefficient of cartilage surface, thickness, matrix metalloproteinase 1, bone-γ-carboxyglutamic acid-containing protein