PF1163A and B, New Antifungal Antibiotics Produced by Penicilium sp. II. Physico-chemical Properties and Structure Elucidation

TORU SASAKI; HIROSHI NOSE; AYAKO HOSOYA; SHIGEMI YOSHIDA; MAMI KAWAGUCHI; TAKASHI WATANABE; TAKAYUKI USUI; YASUO OHTSUKA; TAKASHI SHOMURA; SATOKO TAKANO; KUNIAKI TATSUTA

doi:10.7164/antibiotics.53.38

PF1163A and B, New Antifungal Antibiotics Produced by Penicilium sp.

II. Physico-chemical Properties and Structure Elucidation

TORU SASAKI, HIROSHI NOSE, AYAKO HOSOYA, SHIGEMI YOSHIDA, MAMI KAWAGUCHI, TAKASHI WATANABE, TAKAYUKI USUI, YASUO OHTSUKA, TAKASHI SHOMURA, SATOKO TAKANO, KUNIAKI TATSUTA

Author information

TORU SASAKI
Pharmaceutical Research Center, Meiji Seika, Ltd.
HIROSHI NOSE
Pharmaceutical Research Center, Meiji Seika, Ltd.
AYAKO HOSOYA
Pharmaceutical Research Center, Meiji Seika, Ltd.
SHIGEMI YOSHIDA
Pharmaceutical Research Center, Meiji Seika, Ltd.
MAMI KAWAGUCHI
Pharmaceutical Research Center, Meiji Seika, Ltd.
TAKASHI WATANABE
Pharmaceutical Research Center, Meiji Seika, Ltd.
TAKAYUKI USUI
Pharmaceutical Research Center, Meiji Seika, Ltd.
YASUO OHTSUKA
Pharmaceutical Research Center, Meiji Seika, Ltd.
TAKASHI SHOMURA
Pharmaceutical Research Center, Meiji Seika, Ltd.
SATOKO TAKANO
Department of Applied Chemistry, School of Science and Engineering, Waseda University
KUNIAKI TATSUTA
Department of Applied Chemistry, School of Science and Engineering, Waseda University

JOURNAL FREE ACCESS

2000 Volume 53 Issue 1 Pages 38-44

DOI https://doi.org/10.7164/antibiotics.53.38

Details

Abstract

The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF 1163A differs from PF1163B by having an additional hydroxyl group on the side chain.

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