The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
Biological Activities of Novel Zaragozic Acids, the Potent Inhibitors of Squalene Synthase, Produced by the Fungus, Mollisia sp. SANK 10294
TATSUO TANIMOTO, KIYOSHI HAMANO, KAORI ONODERA, TSUYOSHI HOSOYA, MAYUMI KAKUSAKA, TOMOKO HIRAYAMA, YOKO SHIMADA, TEIICHIRO KOGA, YOSHIO TSUJITA
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1997 Volume 50 Issue 5 Pages 390-394

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Abstract

Four novel zaragozic acids, F-10863 A, B, C and D, were isolated from a culture broth of the fungus Mollisia sp. SANK 10294. F-10863 compounds contain a 4, 6, 7-trihydroxy-2, 8-dioxyobicyclo[3.2.1]octane-3, 4, 5-tricarboxylic acid core like previously reported zaragozic acids, but the structures of the side chains are different. Recently, it was found that F-10863 A is identical to zaragozic acid D3, while the other three are novel compounds. F-10863 compounds are potent inhibitors of squalene synthase like previously reported zaragozic acids, and, furthermore, they exhibit serum cholesterol-lowering activity in vivo.

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The Journal of Antibiotics, Series A

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