PF1092A, B and C, New Nonsteroidal Progesterone Receptor Ligands Produced by Penicillium oblatum I. Taxonomy of Producing Strain, Fermentation, Isolation and Biological Activities

YUJI TABATA; NAOKO MIIKE; MASAHIRO HATSU; YASUSHI KURATA; TAKASHI YAGUCHI; AYAKO SOMEYA; SHINJI MIYADOH; SHIGERU HOSHIKO; TAKASHI TSURUOKA; SHOJI OMOTO

doi:10.7164/antibiotics.50.304

PF1092A, B and C, New Nonsteroidal Progesterone Receptor Ligands Produced by Penicillium oblatum

I. Taxonomy of Producing Strain, Fermentation, Isolation and Biological Activities

YUJI TABATA, NAOKO MIIKE, MASAHIRO HATSU, YASUSHI KURATA, TAKASHI YAGUCHI, AYAKO SOMEYA, SHINJI MIYADOH, SHIGERU HOSHIKO, TAKASHI TSURUOKA, SHOJI OMOTO

Author information

YUJI TABATA
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
NAOKO MIIKE
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
MASAHIRO HATSU
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
Present address: Department of Biotechnology, Faculty of Agriculture, Gifu University
YASUSHI KURATA
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
TAKASHI YAGUCHI
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
AYAKO SOMEYA
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
SHINJI MIYADOH
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
SHIGERU HOSHIKO
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
TAKASHI TSURUOKA
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
SHOJI OMOTO
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.

JOURNAL FREE ACCESS

1997 Volume 50 Issue 4 Pages 304-308

DOI https://doi.org/10.7164/antibiotics.50.304

Details

Abstract

Three new nonsteroidal progesterone receptor ligands, PF1092A, B and C, have been isolated from Penicillium oblatum. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies, and crystallization. All three ligands competitively inhibited [³H]-progesterone binding to porcine uteri cytosol preparations with IG₅₀ of 3.0×10 nM (PF1092A), 2.2×10² nM (PF1092B) and 2.2×10³nM (PF1092C).

Corresponding author

Register with J-STAGE for free!