Monamidocin, a Novel Fibrinogen Receptor Antagonist I. Production, Isolation, Characterization and Structural Elucidation

TSUTOMU KAMIYAMA; TAKAYUKI UMINO; YOSHIKO ITEZONO; YOJIRO ANZAI; NOBORU NAKAYAMA; ASAKO TAKEMAE; TOMOKO SATOH; JUNKO WATANABE; KAZUTERU YOKOSE

doi:10.7164/antibiotics.48.1221

Monamidocin, a Novel Fibrinogen Receptor Antagonist

I. Production, Isolation, Characterization and Structural Elucidation

TSUTOMU KAMIYAMA, TAKAYUKI UMINO, YOSHIKO ITEZONO, YOJIRO ANZAI, NOBORU NAKAYAMA, ASAKO TAKEMAE, TOMOKO SATOH, JUNKO WATANABE, KAZUTERU YOKOSE

Author information

JOURNAL FREE ACCESS

1995 Volume 48 Issue 11 Pages 1221-1225

DOI https://doi.org/10.7164/antibiotics.48.1221

Details

Abstract

Monamidocin, a novel fibrinogen receptor antagonist, has been isolated from the culture broth of Streptomyces sp. NR 6637 by carbon adsorption, n-BuOH extraction, SP-Toyopearl, silica gel 60 silanised and Sephadex LH-20 column chromatographies and preparative HPLC. The molecular formula of monamidocin has been determined to be C₁₅H₂₂N₄O₄ from HRFAB-MS and ¹³C NMR spectral data. The structure of monamidocjn has been determined to be N-[(S)-5-guanidino-2-hydroxypentanoyl]-L-phenylalanine by 2D NMR experiments.

Corresponding author

Register with J-STAGE for free!