SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF PRADIMICIN A DERIVATIVES MODIFICATION OF THE ALANINE MOIETY

MAKI NISHIO; HIROAKI OHKUMA; MASATOSHI KAKUSHIMA; SHIN-ICHI OHTA; SEUI IIMURA; MINORU HIRANO; MASATAKA KONISHI; TOSHIKAZU OKI

doi:10.7164/antibiotics.46.494

MAKI NISHIO, HIROAKI OHKUMA, MASATOSHI KAKUSHIMA, SHIN-ICHI OHTA, SEUI IIMURA, MINORU HIRANO, MASATAKA KONISHI, TOSHIKAZU OKI

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JOURNAL FREE ACCESS

1993 Volume 46 Issue 3 Pages 494-499

DOI https://doi.org/10.7164/antibiotics.46.494

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Abstract

Chemical modifications of the carboxyl group in the alanine moiety of pradimicin A were performed and in vitro and in vivo antifungal activities of the derivatives were examined in comparison with those of pradimicin A. The amide derivatives showed activities comparable to pradimicin A, indicating that the free carboxyl group can be modified without impairing the antifungal activity.

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