SYNTHESIS AND ANTIBACTERIAL PROPERTIES OF 7-[2-(3-SUBSTITUTED-5-ISOXAZOLYL)-2-METHOXYIMINOACETAMIDOJCEPHALOSPORANIC ACID DERIVATIVES

ALBERTO SALA; DARIO CHIARINO; MAURO NAPOLETANO; ENRICO ALBINI; ANGELO CARENZI; DAVIDE BELLA BELLA

doi:10.7164/antibiotics.40.1555

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SYNTHESIS AND ANTIBACTERIAL PROPERTIES OF 7-[2-(3-SUBSTITUTED-5-ISOXAZOLYL)-2-METHOXYIMINOACETAMIDOJCEPHALOSPORANIC ACID DERIVATIVES

ALBERTO SALA, DARIO CHIARINO, MAURO NAPOLETANO, ENRICO ALBINI, ANGELO CARENZI, DAVIDE BELLA BELLA

Author information

JOURNAL FREE ACCESS

1987 Volume 40 Issue 11 Pages 1555-1562

DOI https://doi.org/10.7164/antibiotics.40.1555

Details

Abstract

The synthesis of new 2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetic acids and their condensation derivatives with a suitable cephalosporanic nucleus, is reported. Their antibacterial properties were tested in vivo and in vitro also against β-lactamase producer microorganisms; particularly the oral bioavailability of some of these new derivatives was studied.

Content from these authors

Favorites & Alerts

Corresponding author