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Year 2024, Volume: 50 Issue: 1, 80 - 88, 14.03.2024

Süleyman Akkaya Ümit Çakmak

https://doi.org/10.5798/dicletip.1451645

Abstract

References

  • 1.Naddaf M. Turkey-Syria earthquake: whatscientists know. Nature2023;614:398-399.doi:10.1038/d41586-023-00364-y
  • 2.Efendi GY, Temeltürk RD, Çakmak IB, Dinçer M.Surviving the Immediate Aftermath of a Disaster: APreliminary Investigation of Adolescents' AcuteStress Reactions and Mental Health Needs after the2023 Turkey Earthquakes. Children (Basel)2023;10: 1485. doi:10.3390/children10091485
  • 3.Erdik M, Tümsa M, Pınar A, Altunel E, Zülfikar A. Apreliminary report on the February 6, 2023earthquakes in Türkiye. Research Briefs2023.
  • 4.Srivastava K. Disaster: Challenges andperspectives. Ind Psychiatry J2010;19:1-4.doi:10.4103/0972-6748.77623
  • 5.Kundakci B, Mirioglu A, Tekin M, et al. 6 February2023, orthopedic experience in Kahramanmaraşearthquake and surgical decision in patients withcrush syndrome. J Orthop Surg Res 2023;18:537.doi:10.1186/s13018-023-04001-2
  • 6.Vanholder R, Sever MS, Erek E, Lameire N.Rhabdomyolysis. J Am Soc Nephrol 2000; 11:1553-61.doi:10.1681/asn.V1181553
  • 7.Vanholder R, Sükrü Sever M, Lameire N. Kidneyproblems in disaster situations. Nephrol Ther2021;17s:S27-s36. doi:10.1016/j.nephro.2020.02.009
  • 8.Liu YZ, Wang YX, Jiang CL. Inflammation: TheCommon Pathway of Stress-Related Diseases. FrontHum Neurosci2017; 11:316.doi:10.3389/fnhum.2017.00316
  • 9.Chen L, Deng H, Cui H, et al. Inflammatoryresponses and inflammation-associated diseases inorgans. Oncotarget 2018; 9:7204-18.doi:10.18632/oncotarget.23208
  • 10.Bernardi S, Marcuzzi A, Piscianz E, Tommasini A,Fabris B. The Complex Interplay between Lipids,Immune System and Interleukins in Cardio-Metabolic Diseases. Int J Mol Sci.2018; 19: 4058.doi:10.3390/ijms19124058
  • 11.Ertunc ME, Hotamisligil GS. Lipid signaling andlipotoxicity in metaflammation: indications formetabolic disease pathogenesis and treatment. JLipid Res 2016; 57:2099-114.doi:10.1194/jlr.R066514
  • 12.Cheang I, Zhu X, Lu X, et al. Association ofremnant cholesterol and non-high densitylipoprotein cholesterol with risk of cardiovascularmortality among US general population.Heliyon2022; 8:e10050.doi:10.1016/j.heliyon.2022.e10050
  • 13.Pih GY, Gong EJ, Choi JY, et al. Associations ofSerum Lipid Level with Gastric Cancer Risk,Pathology, and Prognosis. Cancer Res Treat2021;53:445-56. doi:10.4143/crt.2020.599
  • 14.Boizel R, Benhamou PY, Lardy B, et al. Ratio oftriglycerides to HDL cholesterol is an indicator ofLDL particle size in patients with type 2 diabetes andnormal HDL cholesterol levels. Diabetes Care2000;23:1679-85. doi:10.2337/diacare.23.11.1679
  • 15.Pacifico L, Bonci E, Andreoli G, et al. Associationof serum triglyceride-to-HDL cholesterol ratio withcarotid artery intima-media thickness, insulinresistance and nonalcoholic fatty liver disease inchildren and adolescents. Nutr Metab CardiovascDis2014; 24:737-43.doi:10.1016/j.numecd.2014.01.010
  • 16.Yang SH, Du Y, Li XL, et al. Triglyceride to High-Density Lipoprotein Cholesterol Ratio andCardiovascular Events in Diabetics With CoronaryArtery Disease. Am J Med Sci2017;354:117-24.doi:10.1016/j.amjms.2017.03.032
  • 17.Jonas K, Magoń W, Podolec P, Kopeć G.Triglyceride-to-High-Density LipoproteinCholesterol Ratio and Systemic Inflammation inPatients with Idiopathic Pulmonary Arterial Hypertension. Med Sci Monit2019;25:746-53. doi:10.12659/msm.912766
  • 18.Rajagopalan S. Crush Injuries and the CrushSyndrome. Med J Armed Forces India2010; 66:317-20.doi:10.1016/s0377-1237(10)80007-3.
  • 19.Jin H, Lin X, Liu Z, et al. Remote ischemicpostconditioning protects against crush-inducedacute kidney injury via down-regulation ofapoptosis and senescence. Eur J Trauma Emerg Surg2022; 48(6):4585-93. doi:10.1007/s00068-022-01910-5.
  • 20.Yang XY, Song J, Hou SK, et al. Ulinastatinameliorates acute kidney injury induced by crushsyndrome inflammation by modulating Th17/Tregcells. Int Immunopharmacol2020; 81:106265.doi:10.1016/j.intimp.2020.106265
  • 21.Murata I, Abe Y, Yaginuma Y, et al. Astragaloside-IV prevents acute kidney injury and inflammation bynormalizing muscular mitochondrial functionassociated with a nitric oxide protective mechanismin crush syndrome rats. Ann Intensive Care.2017;7:90. doi:10.1186/s13613-017-0313-2.
  • 22.Chen P, Tang Y, He W, et al. PotentialPathophysiological Mechanisms UnderlyingMultiple Organ Dysfunction in Cytokine ReleaseSyndrome. Mediators Inflamm2022; 2022:7137900.doi:10.1155/2022/7137900
  • 23.Khovidhunkit W, Kim MS, Memon RA, et al.Effects of infection and inflammation on lipid andlipoprotein metabolism: mechanisms andconsequences to the host. J Lipid Res. 2004;45:1169-96. doi:10.1194/jlr.R300019-JLR200
  • 24.Wendel M, Paul R, Heller AR. Lipoproteins ininflammation and sepsis. II. Clinical aspects.Intensive Care Med2007; 33:25-35.doi:10.1007/s00134-006-0433-x
  • 25.Peng J, Luo F, Ruan G, Peng R, Li X.Hypertriglyceridemia and atherosclerosis. LipidsHealth Dis2017; 16:233. doi:10.1186/s12944-017-0625-0
  • 26.Parra S, Saballs M, DiNubile M, et al. Low HDL-clevels at admission are associated with greaterseverity and worse clinical outcomes in patientswith COVID-19 disease. Atheroscler Plus 2023;52:1-8.doi:10.1016/j.athplu.2023.01.002
  • 27.Tanaka S, Labreuche J, Drumez E, et al. Low HDLlevels in sepsis versus trauma patients in intensivecare unit. Annals of Intensive Care2017;7:60.doi:10.1186/s13613-017-0284-3
  • 28.Sorokin AV, Karathanasis SK, Yang ZH, et al.COVID-19-Associated dyslipidemia: Implications formechanism of impaired resolution and noveltherapeutic approaches. Faseb j 2020; 34:9843-53.doi:10.1096/fj.202001451
  • 29.Tejera CH, Minnier J, Fazio S, et al. Hightriglyceride to HDL cholesterol ratio is associatedwith increased coronary heart disease among Whitebut not Black adults. Am J Prev Cardiol2021;7:100198. doi:10.1016/j.ajpc.2021.100198
  • 30.Peng F, Lei S, Zhang Q, Zhong Y, Wu S.Triglyceride/High-Density Lipoprotein CholesterolRatio is Associated with the Mortality of COVID-19:A Retrospective Study in China. Int J Gen Med 2022;15:985-96. doi:10.2147/ijgm.S346690

The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims

Year 2024, Volume: 50 Issue: 1, 80 - 88, 14.03.2024

Süleyman Akkaya Ümit Çakmak

https://doi.org/10.5798/dicletip.1451645

Abstract

Background: In the study of vascular and metabolic diseases, the ratio of triglycerides to high-density lipoprotein (HDL) cholesterol (TG/HDL) is crucial. Its significance for earthquake victims hasn't been fully investigated, though. This study investigates the relationship between the TG/HDL ratio and critical care unit admission in earthquake victims.
Methods: Sixty-four patients were enrolled. Both the laboratory results and the clinical features were documented. The TG/HDL ratio's prognostic value for intensive care unit (ICU) admission was then evaluated using ROC curve analysis. Spearman test was applied to analyze correlation between TG/HDL-c and inflammation markers. Logistic regression analysis was then used to elucidate the independent contribution of the TG/HDL-c ratio to the ICU admission risk.
Results: Median age of the cohort was 28 (IQR 17-40) and thirty-seven (57.8%) of the patients were female. 27 patients (42.2%) were admitted to ICU. In the multivariate model, the TG/HDL ratio was associated with higher risk of ICU admission (OR: 1.225, 95% CI: 1.003-1.496, p=0.047). The TG/HDL-c ratio may be a predictor of ICU admissions, according to the ROC curve (AUC: 0.737, 95% CI: 0.610-0.864, p=0.001). The TG/HDL ratio was positively correlated with procalcitonin (r = 0.620, p <0.001), white blood cells (r = 0.253, p = 0.044), and C-reactive protein (r = 0.410, p = 0.001).
Conclusion: The present study suggests a potential role for the TG/HDL ratio as a non-invasive and readily available biomarker for the prediction of ICU admission in the earthquake victims.

Keywords

earthquake crush syndrome triglyceride high density lipoprotein cholesterol inflammation

References

  • 1.Naddaf M. Turkey-Syria earthquake: whatscientists know. Nature2023;614:398-399.doi:10.1038/d41586-023-00364-y
  • 2.Efendi GY, Temeltürk RD, Çakmak IB, Dinçer M.Surviving the Immediate Aftermath of a Disaster: APreliminary Investigation of Adolescents' AcuteStress Reactions and Mental Health Needs after the2023 Turkey Earthquakes. Children (Basel)2023;10: 1485. doi:10.3390/children10091485
  • 3.Erdik M, Tümsa M, Pınar A, Altunel E, Zülfikar A. Apreliminary report on the February 6, 2023earthquakes in Türkiye. Research Briefs2023.
  • 4.Srivastava K. Disaster: Challenges andperspectives. Ind Psychiatry J2010;19:1-4.doi:10.4103/0972-6748.77623
  • 5.Kundakci B, Mirioglu A, Tekin M, et al. 6 February2023, orthopedic experience in Kahramanmaraşearthquake and surgical decision in patients withcrush syndrome. J Orthop Surg Res 2023;18:537.doi:10.1186/s13018-023-04001-2
  • 6.Vanholder R, Sever MS, Erek E, Lameire N.Rhabdomyolysis. J Am Soc Nephrol 2000; 11:1553-61.doi:10.1681/asn.V1181553
  • 7.Vanholder R, Sükrü Sever M, Lameire N. Kidneyproblems in disaster situations. Nephrol Ther2021;17s:S27-s36. doi:10.1016/j.nephro.2020.02.009
  • 8.Liu YZ, Wang YX, Jiang CL. Inflammation: TheCommon Pathway of Stress-Related Diseases. FrontHum Neurosci2017; 11:316.doi:10.3389/fnhum.2017.00316
  • 9.Chen L, Deng H, Cui H, et al. Inflammatoryresponses and inflammation-associated diseases inorgans. Oncotarget 2018; 9:7204-18.doi:10.18632/oncotarget.23208
  • 10.Bernardi S, Marcuzzi A, Piscianz E, Tommasini A,Fabris B. The Complex Interplay between Lipids,Immune System and Interleukins in Cardio-Metabolic Diseases. Int J Mol Sci.2018; 19: 4058.doi:10.3390/ijms19124058
  • 11.Ertunc ME, Hotamisligil GS. Lipid signaling andlipotoxicity in metaflammation: indications formetabolic disease pathogenesis and treatment. JLipid Res 2016; 57:2099-114.doi:10.1194/jlr.R066514
  • 12.Cheang I, Zhu X, Lu X, et al. Association ofremnant cholesterol and non-high densitylipoprotein cholesterol with risk of cardiovascularmortality among US general population.Heliyon2022; 8:e10050.doi:10.1016/j.heliyon.2022.e10050
  • 13.Pih GY, Gong EJ, Choi JY, et al. Associations ofSerum Lipid Level with Gastric Cancer Risk,Pathology, and Prognosis. Cancer Res Treat2021;53:445-56. doi:10.4143/crt.2020.599
  • 14.Boizel R, Benhamou PY, Lardy B, et al. Ratio oftriglycerides to HDL cholesterol is an indicator ofLDL particle size in patients with type 2 diabetes andnormal HDL cholesterol levels. Diabetes Care2000;23:1679-85. doi:10.2337/diacare.23.11.1679
  • 15.Pacifico L, Bonci E, Andreoli G, et al. Associationof serum triglyceride-to-HDL cholesterol ratio withcarotid artery intima-media thickness, insulinresistance and nonalcoholic fatty liver disease inchildren and adolescents. Nutr Metab CardiovascDis2014; 24:737-43.doi:10.1016/j.numecd.2014.01.010
  • 16.Yang SH, Du Y, Li XL, et al. Triglyceride to High-Density Lipoprotein Cholesterol Ratio andCardiovascular Events in Diabetics With CoronaryArtery Disease. Am J Med Sci2017;354:117-24.doi:10.1016/j.amjms.2017.03.032
  • 17.Jonas K, Magoń W, Podolec P, Kopeć G.Triglyceride-to-High-Density LipoproteinCholesterol Ratio and Systemic Inflammation inPatients with Idiopathic Pulmonary Arterial Hypertension. Med Sci Monit2019;25:746-53. doi:10.12659/msm.912766
  • 18.Rajagopalan S. Crush Injuries and the CrushSyndrome. Med J Armed Forces India2010; 66:317-20.doi:10.1016/s0377-1237(10)80007-3.
  • 19.Jin H, Lin X, Liu Z, et al. Remote ischemicpostconditioning protects against crush-inducedacute kidney injury via down-regulation ofapoptosis and senescence. Eur J Trauma Emerg Surg2022; 48(6):4585-93. doi:10.1007/s00068-022-01910-5.
  • 20.Yang XY, Song J, Hou SK, et al. Ulinastatinameliorates acute kidney injury induced by crushsyndrome inflammation by modulating Th17/Tregcells. Int Immunopharmacol2020; 81:106265.doi:10.1016/j.intimp.2020.106265
  • 21.Murata I, Abe Y, Yaginuma Y, et al. Astragaloside-IV prevents acute kidney injury and inflammation bynormalizing muscular mitochondrial functionassociated with a nitric oxide protective mechanismin crush syndrome rats. Ann Intensive Care.2017;7:90. doi:10.1186/s13613-017-0313-2.
  • 22.Chen P, Tang Y, He W, et al. PotentialPathophysiological Mechanisms UnderlyingMultiple Organ Dysfunction in Cytokine ReleaseSyndrome. Mediators Inflamm2022; 2022:7137900.doi:10.1155/2022/7137900
  • 23.Khovidhunkit W, Kim MS, Memon RA, et al.Effects of infection and inflammation on lipid andlipoprotein metabolism: mechanisms andconsequences to the host. J Lipid Res. 2004;45:1169-96. doi:10.1194/jlr.R300019-JLR200
  • 24.Wendel M, Paul R, Heller AR. Lipoproteins ininflammation and sepsis. II. Clinical aspects.Intensive Care Med2007; 33:25-35.doi:10.1007/s00134-006-0433-x
  • 25.Peng J, Luo F, Ruan G, Peng R, Li X.Hypertriglyceridemia and atherosclerosis. LipidsHealth Dis2017; 16:233. doi:10.1186/s12944-017-0625-0
  • 26.Parra S, Saballs M, DiNubile M, et al. Low HDL-clevels at admission are associated with greaterseverity and worse clinical outcomes in patientswith COVID-19 disease. Atheroscler Plus 2023;52:1-8.doi:10.1016/j.athplu.2023.01.002
  • 27.Tanaka S, Labreuche J, Drumez E, et al. Low HDLlevels in sepsis versus trauma patients in intensivecare unit. Annals of Intensive Care2017;7:60.doi:10.1186/s13613-017-0284-3
  • 28.Sorokin AV, Karathanasis SK, Yang ZH, et al.COVID-19-Associated dyslipidemia: Implications formechanism of impaired resolution and noveltherapeutic approaches. Faseb j 2020; 34:9843-53.doi:10.1096/fj.202001451
  • 29.Tejera CH, Minnier J, Fazio S, et al. Hightriglyceride to HDL cholesterol ratio is associatedwith increased coronary heart disease among Whitebut not Black adults. Am J Prev Cardiol2021;7:100198. doi:10.1016/j.ajpc.2021.100198
  • 30.Peng F, Lei S, Zhang Q, Zhong Y, Wu S.Triglyceride/High-Density Lipoprotein CholesterolRatio is Associated with the Mortality of COVID-19:A Retrospective Study in China. Int J Gen Med 2022;15:985-96. doi:10.2147/ijgm.S346690
There are 30 citations in total.

Details

Primary Language English
Subjects Medical Education
Journal Section Original Articles
Authors

Süleyman Akkaya

Ümit Çakmak

Publication Date March 14, 2024
Submission Date January 18, 2024
Acceptance Date February 28, 2024
Published in Issue Year 2024 Volume: 50 Issue: 1

Cite

APA Akkaya, S., & Çakmak, Ü. (2024). The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims. Dicle Tıp Dergisi, 50(1), 80-88. https://doi.org/10.5798/dicletip.1451645
AMA Akkaya S, Çakmak Ü. The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims. diclemedj. March 2024;50(1):80-88. doi:10.5798/dicletip.1451645
Chicago Akkaya, Süleyman, and Ümit Çakmak. “The Role of triglyceride/High-Density Lipoprotein Cholesterol Ratio in the Prediction of Intensive Care Unit Admission in the Earthquake Victims”. Dicle Tıp Dergisi 50, no. 1 (March 2024): 80-88. https://doi.org/10.5798/dicletip.1451645.
EndNote Akkaya S, Çakmak Ü (March 1, 2024) The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims. Dicle Tıp Dergisi 50 1 80–88.
IEEE S. Akkaya and Ü. Çakmak, “The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims”, diclemedj, vol. 50, no. 1, pp. 80–88, 2024, doi: 10.5798/dicletip.1451645.
ISNAD Akkaya, Süleyman - Çakmak, Ümit. “The Role of triglyceride/High-Density Lipoprotein Cholesterol Ratio in the Prediction of Intensive Care Unit Admission in the Earthquake Victims”. Dicle Tıp Dergisi 50/1 (March 2024), 80-88. https://doi.org/10.5798/dicletip.1451645.
JAMA Akkaya S, Çakmak Ü. The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims. diclemedj. 2024;50:80–88.
MLA Akkaya, Süleyman and Ümit Çakmak. “The Role of triglyceride/High-Density Lipoprotein Cholesterol Ratio in the Prediction of Intensive Care Unit Admission in the Earthquake Victims”. Dicle Tıp Dergisi, vol. 50, no. 1, 2024, pp. 80-88, doi:10.5798/dicletip.1451645.
Vancouver Akkaya S, Çakmak Ü. The role of triglyceride/high-density lipoprotein cholesterol ratio in the prediction of intensive care unit admission in the earthquake victims. diclemedj. 2024;50(1):80-8.
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