Mosquitoes are responsible for transmitting pathogens of many diseases such as malaria, filariasis, dengue haemorrhagic fever and chikunguinya than any other group of arthropods. The present studywas undertaken to evaluate larvicidal efficacy of Vitex negundo, Clerodendrum inerme andGliricidia sepium individually and synergistic activities combined with Pongamia glabra seedextract against early fourth instar dengue vector mosquito, Aedes aegypti. In the acute toxicity tests against the early fourth instar A. aegypti larval mortality increased with increased concentrations of the extract. The results revealed that, C. inerme found to be more toxic plant when testedindividually. The maximum synergistic activities were found in the combination extracts of V. negundo with P. glabra (50: 50). These results are significantly effective than the combinationextract ratio of C. inerme with P. glabra (50:50) and G. sepium with P. glabra (50:50) followed byother combinations with concentrations. The results of study revealed that Vitex negundo, Clerodendrum inerme plant leaves individual and/or combinations with extracts of P. glabra can beused as potent source of natural mosquito larvicidal agent.