As globalization increases, it is ever more important to gain an understanding of the determinants of job satisfaction in different cultural contexts. This research examined person-job fit and professional tenure as antecedents of job satisfaction in nurses in both Japan and Canada. Regression analyses suggest that professional tenure provides little independent contribution to variation in either person-job fit or job satisfaction in either cultural context. Person-job fit, however, had a strong relationship with job satisfaction even after controlling for age and professional tenure. Contrary to expectation, no interaction between person-job fit and professional tenure was found in either Japan or Canada. Also unexpectedly, age was a significant predictor of job satisfaction only in the Canadian sample. Implications for theory and application are discussed.