Compatibility of lactase preparations (G-TT, O-ON, L-WM, L-NK, ORG) with 20 other drugs was studied. The samples mixed with the drugs were wrapped with polyethylene-glassine and observed for the change in appearance and activities for 28 days under 3 different conditions: 5±1°, RH 40-50%; 25±1°, RH 75%; 30±1°, RH 90-92%. Then, compatibility of the lactase preparations was compared with each other.
In the above study, the samples mixed with G-TT indicated the fastest change, while those mixed with L-NK, ORG, O-ON and L-WM showed evidently different compatibility from that of the others. In spite of the preparations of the same component, a significant difference was recognized between them. Most of them corresponded with each other in the change of appearance and decrease of activities. It is also important that one must be carefull with a case resulting only in decrease of activities when lactase is mixed with acid or alkaline agents.