In recent years, Mohs chemosurgery has been reported to be beneficial for the management of bleeding and exudation by unresectable cancer skin invasion. However, Mohs paste is difficult to use because it melts by exudate. Furthermore, Mohs paste is unsuitable for long-term use because it solidifies in a few days after preparation. Thus, we developed a modified Mohs paste in order to address these problems. The composition of modified Mohs paste is Mohs paste and Zinc oxide 10% single ointment, the weight ratio is 1:1. Although modified Mohs paste has a slower tissue fixation effect than Mohs paste, the risk of injuring surrounding normal skin is less than that of Mohs paste because it does not collapse in the exudate. Furthermore, modified Mohs paste is available for use in emergency situations because it can be stored for more than 3 months in a usable form. Modified Mohs paste is useful in the management of tumor exudate.