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HomeInternational Letters of Chemistry, Physics and...International Letters of Chemistry, Physics and...Analgesic and Anti-Inflammatory Activities of some...

Analgesic and Anti-Inflammatory Activities of some Transition Metal Schiff Base Complexes

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Abstract:

Analgesic and anti-inflammatory activities of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylideneglycinato diaqua cobalt(II) dimer] (SGCo)2, [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)2, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylideneglycinato diaqua zinc(II) dimer] (SGZ)2 were studied in swiss albino mice. 10 mg/kg (p.o) dose for each compound were selected throughout the research work. The analgesic activity was determined by acetic acid induced writhing and tail immersion methods. All such data were compared with standard drugs at the dose of 10 mg/kg (p.o. The anti-inflammatory activity of the test compounds was determined by the carragenan induced mice paw edema inhibition method.). Analgesic and anti-inflammatory activities of the test compounds at 10 mg/kg (p.o.) were quite comparable to those of standard drugs at 10 mg/kg (p.o.). All these compounds can be considered as potent analgesic and anti-inflammatory agents.

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Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 27)

Pages:

64-72

DOI:

https://doi.org/10.56431/p-q0p682

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Cite this paper

Online since:

February 2014

Authors:

Mele Jesmin, M. Khairul Islam*, Shaikh M. Mohsin Ali

Keywords:

Analgesic Activity, Anti-Inflammatory Activity, Schiff Bases Complexes

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Creative Commons CC BY 4.0

* - Corresponding Author

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