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The role of disordered angiogenesis tissue markers (sflt-1, Plgf) in present day diagnosis of preeclampsia
Affiliations- Clinical Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Poland
- Clinical Department of Internal Medicine, Nephrology and Transplantation, Pomeranian Medical University in Szczecin, Poland
open access
Abstract
Preeclampsia and conditions associated with impaired placental perfusion develop in almost 10% of all pregnancies. Patho- logic angiogenesis is one of the processes observed in preeclampsia. sFlt-1, PlGF and the sFlt-1/PlGF ratio are new and promising angiogenesis-related biomarkers. Our paper describes the present status of, and clinical practice opportunities for, these factors.
According to present data, sFlt-1, PlGF and the sFlt-1/PlGF ratio are very useful tools in assessing placental angiogenesis abnormalities associated with preeclampsia and can be use in clinical practice.
Abstract
Preeclampsia and conditions associated with impaired placental perfusion develop in almost 10% of all pregnancies. Patho- logic angiogenesis is one of the processes observed in preeclampsia. sFlt-1, PlGF and the sFlt-1/PlGF ratio are new and promising angiogenesis-related biomarkers. Our paper describes the present status of, and clinical practice opportunities for, these factors.
According to present data, sFlt-1, PlGF and the sFlt-1/PlGF ratio are very useful tools in assessing placental angiogenesis abnormalities associated with preeclampsia and can be use in clinical practice.
Keywords
sFlt-1; PlGF; preeclampsia
About this articleTitle
The role of disordered angiogenesis tissue markers (sflt-1, Plgf) in present day diagnosis of preeclampsia
Journal
Issue
Article type
Review paper
Pages
173-176
Published online
2019-03-29
Page views
2485
Article views/downloads
1744
DOI
Pubmed
Bibliographic record
Ginekol Pol 2019;90(3):173-176.
Keywords
sFlt-1
PlGF
preeclampsia
Authors
Sebastian Kwiatkowski
Ewa Kwiatkowska
Andrzej Torbe
References (30)- Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009; 33(3): 130–137.
- Wallis AB, Saftlas AF, Hsia J, et al. Secular trends in the rates of preeclampsia, eclampsia, and gestational hypertension, United States, 1987-2004. Am J Hypertens. 2008; 21(5): 521–526.
- Goldenberg RL, Rouse DJ. Prevention of premature birth. N Engl J Med. 1998; 339(5): 313–320.
- Goldenberg RL, et al. Epidemiology and causes of preterm birth. Lancet. 2008; 371(9606): 75–84.
- Ness RB, Sibai BM. Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia. Am J Obstet Gynecol. 2006; 195(1): 40–49.
- Orabona R, Donzelli CM, Falchetti M, et al. Placental histological patterns and uterine artery Doppler velocimetry in pregnancies complicated by early or late pre-eclampsia. Ultrasound Obstet Gynecol. 2016; 47(5): 580–585.
- Bahado-Singh R, Syngelaki A, Mandal R, et al. Metabolomic determination of pathogenesis of late-onset preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine. 2016; 30(6): 658–664.
- Romero R, Nien JK, Espinoza J, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med. 2008; 21(1): 9–23.
- Jardim LL, Rios DR, Perucci LO, et al. Is the imbalance between pro-angiogenic and anti-angiogenic factors associated with preeclampsia? Clin Chim Acta. 2015; 447: 34–38.
- Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest. 2003; 111(5): 707–716.
- Wikström AK, Larsson A, Eriksson UJ, et al. Placental growth factor and soluble FMS-like tyrosine kinase-1 in early-onset and late-onset preeclampsia. Obstet Gynecol. 2007; 109(6): 1368–1374.
- Schrey-Petersen S, Stepan H. Anti-angiogenesis and Preeclampsia in 2016. Curr Hypertens Rep. 2017; 19(1): 6.
- Chaiworapongsa T, Romero R, Kim YM, et al. Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia. J Matern Fetal Neonatal Med. 2005; 17(1): 3–18.
- Leona CY. Poon, Nikos A. Kametas, NereaMaiz, Ranjit Akolekar and Kypros H. Nicolaides. First-Trimester Prediction of Hypertensive Disorders in Pregnancy Hypertension. 2009; 53: 812–818.
- Wright D, Gallo DM, Gil Pugliese S, et al. Contingent screening for preterm pre-eclampsia. Ultrasound Obstet Gynecol. 2016; 47(5): 554–559.
- Gallo D, Wright D, Casanova C, et al. Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 19–24 weeks’ gestation. American Journal of Obstetrics and Gynecology. 2016; 214(5): 619.e1–619.e17.
- Rana S, Powe CE, Salahuddin S, et al. Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia. Circulation. 2012; 125(7): 911–919.
- Lapaire O, et al. , European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010; 151: 122–129.
- Stepan Implementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in signleton pregnancy: imlpication for clinical practic. UltrasoundObstetGynecol. 2015; 45: 241–246.
- Vatish M, Strunz-McKendry T, Hund M, et al. sFlt-1/PlGF ratio test for pre-eclampsia: an economic assessment for the UK. Ultrasound Obstet Gynecol. 2016; 48(6): 765–771.
- Zeisler H, Llurba E, Chantraine F, et al. Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio and Time to Delivery in Women With Suspected Preeclampsia. Obstet Gynecol. 2016; 128(2): 261–269.
- Sovio U, Gaccioli F, Cook E, et al. Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio: A Prospective Cohort Study of Unselected Nulliparous Women. Hypertension. 2017; 69(4): 731–738.
- Dragan I, Wright D, Fiolna M, et al. Development of pre-eclampsia within 4 weeks of sFlt-1/PlGF ratio > 38: comparison of performance at 31-34 vs 35-37 weeks' gestation. Ultrasound Obstet Gynecol. 2017; 49(2): 209–212.
- Romero R, Nien JK, Espinoza J, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med. 2008; 21(1): 9–23.
- Veas CJ, Aguilera VC, Muñoz IJ, et al. Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia. J Matern Fetal Neonatal Med. 2011; 24(11): 1371–1377.
- Litwinska M, Wright D, Efeturk T, et al. Proposed clinical management of pregnancies after combined screening for preeclampsia at 19-24 weeks' gestation. UltrasoundObstetGynecol. ; 2017: Jan.
- Wright D, Dragan I, Syngelaki A, et al. Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 30-34 weeks' gestation. Ultrasound Obstet Gynecol. 2017; 49(2): 194–200.
- Panaitescu AM, Wright D, Militello A, et al. Proposed clinical management of pregnancies after combined screening for pre-eclampsia at 35-37 weeks' gestation. Ultrasound Obstet Gynecol. 2017; 50(3): 383–387.
- Kwiatkowski S, Dołęgowska B, Kwiatkowska E, et al. A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction. PLoS One. 2016; 11(10): e0165060.
- Signore C, Mills JL, Qian C, et al. Circulating angiogenic factors and placental abruption. Obstet Gynecol. 2006; 108(2): 338–344.
