Original Articles
Fluvastatin Increases LDL Particle Size and Reduces Oxidative Stress in Patients with Hyperlipidemia
2003 Volume 10 Issue 6 Pages 343-347
Details
2003 Volume 10 Issue 6 Pages 343-347
The effects of fluvastatin on levels of urinary 8-iso-prostaglandin F2α (iPF2αIII), a marker of oxidative stress, and low-density lipoprotein (LDL) particle size in serum were investigated in patients with hypercholesterolemia. After 6 months of fluvastatin therapy, levels of urinary iPF2αIII decreased from 1, 720.1 ± 392.0 to 539.6 ± 75.5 pg/mg (p < 0.01), and LDL particle size increased from 24.3 ± 0.3 to 26.5 ± 0.2 nm (p < 0.001). These changes from the treatment of fluvastatin were not correlated with those of the serum LDL cholesterol (LDL-C) levels. The results imply that fluvastatin, with its unique antioxidant property among statins, reduces oxidative stress and increases LDL particle size simultaneously in hyperlipidemic patients.
