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MedNext Journal of Medical and Health Sciences
Review
DOI: 10.54448/mdnt22307
Submitted: 08-28-2022
Published: 08-28-2022

Major considerations and clinical findings on the allergic conjunctivitis: a narrative and systematic review

Unioftal - Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
Unioftal - Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
Unioftal - Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
Unioftal - Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
Unioftal - Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
Unioftal - Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil
Allergic Conjunctivitis Immunological Aspects Allergic Eye Diseases Monoclonal Antibodies Immunotherapy

Abstract

Introduction: Allergic conjunctivitis (AC) is a disease of increasing prevalence, affecting children and adults, with progressive loss of quality of life. It has been reported that about 20 % of the entire human population undergoes a form of allergy. The prevalence of allergic conjunctivitis (AC) varies around the world, usually ranging from 15 to 40 %. In Japan, the prevalence of allergic diseases is the conjunctiva is estimated to be as high as 15% -20% of the population is on the rise. Objective: the present objective was to carry out a narrative and systematic review of the major clinical considerations of allergic conjunctivitis, as well as the main treatments, immunological aspects, and allergic conjunctivitis classification. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from May to June 2022 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. Scientific articles from the last 20 years were selected. The quality of the studies was based on the GRADE instrument. The risk of bias was analyzed according to the Cochrane instrument. Results: A total of 512 articles were found, and 35 articles were included in the systematic review. Allergic conjunctivitis (AC) is an inflammation of the conjunctiva secondary to an immune response to foreign antigens, usually called allergens. This inflammation can be mediated or non-IgE and atopy could play a significant role in the outcome. These forms include seasonal and perennial allergic conjunctivitis, vernal keratoconjunctivitis and atopic keratoconjunctivitis. Giant papillary conjunctivitis and contact or induced by dermatoconjunctivitis drugs are considered to be allergic conjunctivitis subtypes. Conclusion: It was concluded that allergic conjunctivitis is a frequent comorbid with many undiagnosed patients. Then, an additional specific questioning and a therapeutic challenge in suspected patients may help identify patients who may benefit from treatment of Allergic conjunctivitis.

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References

  1. Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P. ICON: Diagnosis and management of allergic conjunctivitis. Ann Allergy Asthma Immunol. 2020 Feb;124(2):118-134. doi: 10.1016/j.anai.2019.11.014.
  2. Villegas BV, Benitez-Del-Castillo JM. Current Knowledge in Allergic Conjunctivitis. Turk J Ophthalmol. 2021 Feb 25;51(1):45-54. doi: 10.4274/tjo.galenos.2020.11456.
  3. Bielory L, Delgado L, Katelaris CH, Leonardi A, Rosario N, Vichyanoud P. ICON: Diagnosis and management of allergic conjunctivitis. Ann Allergy Asthma Immunol. 2020 Feb;124(2):118-134. doi: 10.1016/j.anai.2019.11.014.
  4. Sánchez-Hernández MC, Montero J, Rondon C, Benítez del Castillo JM, Velázquez E, Herreras JM, Fernández-Parra B, Merayo-Lloves J, Del Cuvillo A, Vega F, Valero A, Panizo C, Montoro J, Matheu V, Lluch-Bernal M, González ML, González R, Dordal MT, Dávila I, Colás C, Campo P, Antón E, Navarro A. Consensus Document on Allergic Conjunctivitis (DECA). J Investig Allergol Clin Immunol; 2015, 25(2): 94-106.
  5. Sacchetti M, Lambiase A, Moretti C, Mantelli F, Bonini, S. Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis. Journal of Immunology Research, 2015, Article ID 945317.
  6. De Bruin Weller MS, Rockmann H, Knulst AC, Bruijnzeel- Koomen FM. Evaluation of the adult patient with atopic dermatitis. Clin Exp Allergy. 2013;43:279-91.
  7. O’Brien TP. Allergic conjunctivitis: an update on diagnosis and management. Curr Opin Allergy Clin Immunol; 2013, 13:543- 9.
  8. Lin SY, Erekosima N, Suarez-Cuervo C, Ramanathan M, Kim JM, Ward D, Chelladurai Y, Segal JB. Allergen- Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013, Mar. Report No.: 13-EHC061EF.
  9. Demoly P, Calderon MA, Casale T, Scadding G, Annesi- Maesano I, Braun JJ, Delaisi B, Haddad T, Malard O, Trebuchon F, Serrano E. Assessment of disease control in allergic rhinitis. ClinTransl Allergy; 2013, 3:1-7.
  10. Gomes PJ, Ousler GW, Welch DL, Smith LM, Coderre J, Abelson M. Exacerbation of signs and symptoms of allergic conjunctivitis by a controlled adverse environment challenge in subjects with a history of dry eye and ocular allergy. Clin Ophthalmol; 2013, 7:157-65.
  11. Gane J, Buckley R. Leukotriene receptor antagonist sine allergic eye disease: A systematic review and meta-analysis. JAllergy Clin Immunol: In practice; 2013, 1:65-74.
  12. Fujishima H, Satake Y, Okada N, Kawashima S, Matsumoto K, Hirohisa S. Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium. Ann Allergy Asthma Immunol; 2013, 110:39-43.
  13. Bielory L. Allergic conjunctivitis: the evolution of therapeutic options. Allergy Asthma Proc; 2012, 33:129-39.
  14. Lightman S, Scadding GK. Should intranasal corticosteroids be used for the treatment of ocular symptoms of allergic rhinoconjunctivitis? A review of their efficacy and safety profile. Int Arch Allergy Immunol; 2012, 158:317-25.
  15. Bilkhu PS, Wolffsohn JS, Naroo AS. A review of nonpharmacological and pharmacological management of seasonal and perennial allergic conjunctivitis. Cont Lens Anterior Eye; 2012, 35:9-16.
  16. Friedlaender MH. Ocular allergy. Curr Opin Allergy Clin Immunol; 2011, 11:477-82.
  17. Sanchez MC, Fernandez Parra B, Matheu V, Navarro A, Ibanez MD, Davila I, Dordal MT, Lluch Bernal M, Rondon C, Montoro J, Anton E, Colas C, Valero A. (SEAIC Rhinoconjunctivitis Committee 2010). Allergic Conjunctivitis. J Investig Allergol Clin Immunol. 2011, ;21 Suppl 2:1-19.
  18. Bousquet PJ, Bachert C, Canonica GW, Casale TB, Mullol J, Klossek JM, Zuberbier T, Bousquet J. Uncontrolled allergic rhinitis during treatment and its impact on quality of life: a cluster randomized trial. J Allergy Clin Immunol; 2010, 126:666-8.
  19. Palmares J, Delgado L, Cidade M, Quadrado MJ, Filipe HP (2010). Allergic conjunctivitis: a national cross-sectional study of clinical characteristics and quality of life. Eur J Ophthalmol. ;20:257-64.
  20. Picado C, Badiola C, Perulero N, Sastre J, Olaguibel JM, Lopez -Vina A, Vega JM. Covalair Investigator Group. Validation of de Spanish version of the Asthma Control Questionnaire. Clin Ther. 2008, 30:1918-31.
  21. Singh K, Bielory L, Hackensack NJ, Newark NJ. Epidemiology of ocular allergy symptoms in United States adults (1988-1994). Ann Allergy Asthma Immunol.; 2007, 98:A22:34.
  22. S. Bonini, M. Sacchetti, F. Mantelli, and A (2007). Lambiase, “Clinical grading of vernal keratoconjunctivitis,” Current Opinion in Allergy and Clinical Immunology, vol. 7, no. 5, pp. 436–441.
  23. Vega JM, Badia X, Badiola C, Lopez-Vina A, Olaguibel JM, Picado C, Sastre J, Dal-Re R. Covalair Investigator Group. Validation of the Spanish version of the Asthma Control Test (ACT). J Asthma; 2007, 44:867-72.
  24. Murphy PJ, Lau JS, Sim MM, Woods RL. How red is a white eye? Clinical grading of normal conjunctival hyperemia. Eye. 2007, 21:5:633-8.
  25. Valero A, Alonso J, Antepara I, Baro E, Colas C, del Cuvillo A, Ferrer M, Herdman M, Marti-Guadano E, Monclus L, Navarro- Pulido AM, Sastre J, Izquierdo I, Mullol J (2007). Health-related quality of life in allergic rhinitis: comparing the short form ESPRINT-15 and MiniRQLQ questionnaires. Allergy; 62:1372-8.
  26. Martinez CF. Caracteristicas generales de la muestra: descripcion sociodermografica y sanitaria de la poblacion de estudio. In: Alergologica 2005. Factores epidemiologicos, clinicos y socioeconomicos de las enfermedades alergicas em Espana en 2005. SEAIC and Schering-Plough eds. Madrid: Luzan, 2006, 5; p. 71-106.
  27. Leonardi A, Busca F, Motterle L. “Case series of 406 vernal keratoconjunctivitis patients: a demographic and epidemiological study,” Acta Ophthalmologica Scandinavica, 2006, vol. 84, no. 3, pp. 406–410.
  28. Uekert, SJ, Akan, G, Evans, MD (2006). “Sex-related differences in immune development and the expression of atopy in early childhood,”The Journal of Allergy and Clinical Immunology, vol. 118, no. 6, pp. 1375–1381, 2006.
  29. Leonardi, A (2002). “Vernal keratoconjunctivitis: pathogenesis and treatment,” Progress in Retinal and Eye Research, vol. 21, no. 3, pp. 319–339.
  30. Efron N, Morgan PB, Katsara SS (2001). Validation of grading scales for contact lens complications. Ophthal Physiol Opt; 21:17-29.
  31. Bonini, A. Lambiase, S. Marchi (2000). “Vernal keratoconjunctivitis revisited: a case series of 195 patients with long-term followup,” Ophthalmology, 2000, vol. 107, no. 6, pp. 1157–1163.
  32. Bielory L. “Allergic and immunologic disorders of the eye. Part II: ocular allergy,” The Journal of Allergy and Clinical Immunology, 2000, vol. 106, no. 6, pp. 1019–1032.
  33. Juniper EF, Thompson AK, Ferrie PJ, Roberts JN. Validation of the standardized version of the Rhinoconjunctivitis Quality of Life Questionnaire. J Allergy Clin Immunol; 1999, 104(2 Pt 1):364-9.
  34. Willingham FF, Cohen KL, Coggins JM, Tripoli NK, Ogle JW, Goldstein GM. Automatic quantitative measurement of ocular hyperemia. Curr Eye Res; 1995, 14: 1101-08.
  35. McMonnies CW, Ho A. Conjunctival hyperemia in non-contact lens wearers. Acta Ophthalm; 1991, 69:6:799-801.

How to Cite

Moura, M. I. P., Murad, A. C. S., Ferrari, R. S., Daher, I. D., Neiva, E. B., & Liedtke, F. S. (2022). Major considerations and clinical findings on the allergic conjunctivitis: a narrative and systematic review. MedNEXT Journal of Medical and Health Sciences, 3(3). https://doi.org/10.54448/mdnt22307