A 82-year old woman visited our hospital after having suffered from hoarseness for one year and dyspnea for several days. Clinical examination revealed a swelling of the left vocal cord and subglottic region. An emergency tracheostomy was performed under local anesthesia. Five days later, direct microscopic laryngoscopy was performed under general anesthesia and several biopsies of laryngeal lesion were taken following an extirpation that was as complete as possible. The lesion was diagnosed as plasma cell granuloma by histological and immuno-histochemical examination. The hoarseness and dyspnea disappeared after surgical excision followed by successful treatment with steroid administration. Only four cases, including this case, of laryngeal plasma cell granuloma were reported.