ABSTRACT

The present research work was aimed to develop nasal mucoadhesive microspheres of chlorpheniramine maleate (CPM) & to compare its permeation rate through sheep nasal mucosa and cellulose acetate membrane. The impact of different concentrations of polymer and the dispersion media were evaluated for drug permeation, mucoadhesion, FT-IR and DSC studies. With the increase in polymer concentration, it was observed that the particle size and wall thickness of the microsphere increased; while the in-vitro drug permeation through sheep nasal mucosa significantly decreased when the volume of dispersion media was increased. Histopathological studies show the absence of epithelial cilia destruction. The permeation rate through sheep nasal mucosa was found to be 7.968 µg/hr/cm2, while through cellulose acetate (artificial) membrane showed 8.572 μg/hr/cm2. In conclusion, our results indicate that CPM released from chitosan microspheres penetrate well through sheep nasal mucosa, indicating suitability for nasal administration.