Assessment of ghrelin and resistin levels in a group of obese men with metabolic syndrome
1 Faculty of Pharmacy of Monastir, Tunisia.
2 Laboratory of Biochemistry and Biotechnology Faculty of Sciences of Tunis - LR01ES05, Tunisia.
3 Director of Nutrition Department - Higher School of Health Sciences and Techniques of Tunis, Tunisia.
4 Head of Diabetology and Therapeutic Dietetics - National Institute of Nutrition, Tunisia.
5 University of Tunis el Manar, Faculty of Medicine of Tunis, Tunisia.
6 Obesity Unit of the National Institute of Nutrition and Food Technology of Tunis; UR18ES01, Tunisia.
7 Department A of the National Institute of Nutrition of Tunis, Tunisia.
Research Article
International Journal of Biological and Pharmaceutical Sciences Archive, 2024, 07(01), 085–094.
Article DOI: 10.53771/ijbpsa.2024.7.1.0021
Publication history:
Received on 12 January 2024; revised on 01 March 2024; accepted on 04 March 2024
Abstract:
Background: Obesity is a chronic disease associated with numerous complications, including metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Adipose tissue functions as an endocrine organ, producing hormones that play a crucial role in regulating metabolic homeostasis, such as ghrelin and resistin.
Objective: The aim of this study was to compare the levels of resistin and ghrelin in obese men with metabolic syndrome and age-matched men without metabolic syndrome.
Methods: Anthropometric measurements and biochemical assays were conducted to assess glycemia, resistin levels, insulin levels, and ghrelin levels.
Results: The study comprised 58 obese men with metabolic syndrome and 53 age-matched control group men. In obese individuals, there was a significant increase in insulin and resistin levels, while ghrelin levels were notably decreased compared to the control group. Additionally, a positive correlation was observed between resistin levels and parameters such as BMI, waist circumference, and insulin levels.
Conclusion: The findings from this study suggest that both resistin and ghrelin may serve as potential biomarkers for identifying metabolic syndrome in obese men.
Keywords:
Ghrelin; Obesity; Metabolic syndrome; Insulin
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