A multidrug- resistance pattern of an Escherichia coli strain isolated from diarrheal stools at the China-Guinea Friendship Hospital of Kipé in Conakry
1 Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Commune Ratoma 30 BP: 710 Conakry, Republic of Guinea.
2 Department of Medicine, Faculty of Health Sciences and Techniques, Chair of Fundamental Sciences, Gamal Abdel Nasser University of Conakry, PO Box: 1147 Republic of Guinea.
3 Microbiology Laboratory, Department of Biology, Faculty of Sciences, and Gamal Abdel Nasser University of Conakry BP: 1147 Republic of Guinea
Research Article
World Journal of Biological and Pharmaceutical Research, 2022, 03(02), 018-023.
Article DOI: 10.53346/wjbpr.2022.3.2.0043
Publication history:
Received on 22 October 2022; revised on 29 November 2022; accepted on 02 December 2022
Abstract:
Introduction: Diarrheal infections associated to multidrug resistant bacteria are a public health problem, particularly in the tropics.
Objective: The aim of this study was to describe a Multidrug resistant strain of Escherichia coli (E. coli) isolated from diarrheal stools.
Patients and methods: A sample of diarrheal stools from a 30 years old housekeeper patient was analysed at China-Guinea Friendship Hospital of Kipé/Conakry. Parasitological examination by optical microscopy, followed by bacteriological analysis were done. Cultures were carried out on different agar media. Bacterial identification, antibiograms and minimum inhibitory concentrations (MIC) were performed using the Vitek 2 System.
Results: The isolated E. coli strain was sensitive only to 4 of 29 antibiotics tested including imipenem, ertapenem, amikacin and nitrofurantoin. Intermediate sensitivity was detected towards minocycline. In contrast, this strain was resistant to piperacillin, cefuroxime, cefuroxime axetil, cefixime, ceftriaxone, cefepime, aztreonam, meropenem, levofloxacin, ofloxacin, tetracycline, tigecycline, chloramphenicol, trimethoprim, ampicillin, amoxicillin/clavulanic acid, ticarcillin, piperacillin/tazobactam, cephalothin, cefotaxime, ceftazidime, gentamicin, tobramycin, nalidixic acid, ciprofloxacin, ofloxacin and trimethoprim/sulfamethoxazole with high MICs.
Conclusion: The treatment of this multidrug-resistant Escherichia coli diarrheal infection requires appropriate antibiotic therapy, based on the results of an accurate antibiogram to be performed with rapid means for better patient care.
Keywords:
Escherichia coli; Diarrheal stools; Multidrug-resistance; Antibiotics; Kipé/Conakry
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