Choline chloride based eutectic solvent: a highly efficient reaction media for the synthesis of 3,4-dihydropyrimidin-2(1H)-thiones
DOI:
https://doi.org/10.52547/jcc.4.3.4Keywords:
Deep Eutectic Solvent, Green solvent, Dihydropyrimidine, Multicomponent, Biginelli condensationAbstract
A mild and green protocol was developed to the 3,4-dihydropyrimidin-2(1H)-thione derivatives preparation in deep eutectic solvent without the use of a catalyst or any other additive. The procedure offers a number of benefits, including clean reaction profile, avoiding the use of typical toxic catalysts, an easy workup procedure, short reaction times, and low prices.
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