(Case 1) A 62-year-old man suffered from psoriasis for several decades and was treated with ultraviolet A. He noticed a tumor on the right side of his scrotum 10 months ago. A biopsy specimen of the tumor led us to the diagnosis of squamous cell carcinoma (SCC) . Wide excision and right inguinal lymph node dissection were performed. Inspite of the treatment, paraaortic lymph node and lung metastases developed 18 months later. Combination chemotherapy (carboplatin, 5-FU, and peplomycin) could not inhibit the tumor progression and he died 3 years after the first visit.
(Case 2) A 42-year-old man presented with a tumor on the left side of his scrotum. He had worked at an ironworks and used machine oil. After wide excision and left inguinal lymph node dissection, he was treated with 3 courses of peplomycin chemotherapy. The tumor recurred locally 4 years later and was surgically removed again. He has been tumor-free for more than 6 years.
(Case 3) A 77-year-old man, who also worked at an ironworks before, had a tumor on the left side of his scrotum and had it resected at another hospital 4 years ago. Local recurrence occurred and was widely excised. He has been tumor-free for more than 4 years.
During the past 11 years, we experience 251 cases of SCC in our institutions. Among them, 3 cases developed on the scrotum. It is often indicated that SCC occurs on the scrotum soaked with machine oil or exposed to ultraviolet rays. [Skin Cancer (Japan) 2004; 19: 181-185]