Cytofluorometric analysis were performed on paraffin-embedded sections of hair follicle carcinoma. We classified hair follicle carcinoma as malignant proliferating trichilemmal tumor (MPTT) and malignant trichilemmoma (MT) by Morioka's classification.
In 12 cases of MPTT, ten cases showed aneuploid pattern of the histogram, two showed polyploid pattern. The average nuclear DNA content ranged from 2.81C to 5.11C. There was no significant difference of the average nuclear DNA cotent between non-metastatic MPTT and metastatic MPTT.
In 11 cases of MT, eight cases showed aneuploid pattern, three showed diploid pattern. The average nuclear DNA content ranged from 2.20C to 6.43C. The presence of aneuploid pattern was assumed to be the criteria for malignancy. There was not a significnant correlation between the clinical course and the incidence of aneuploiod pattern in MT.
These results indicate that Cytofluorometric methods are not satisfactory for predicting the behavior of individual cases of malignancy in MPTT and MT.