Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?

Maher Kurdi; Heba Alkhatabi; Nadeem Butt; Hameedah Albayjani; Hessa Aljhdali; Fawaz Mohamed; Taghreed Alsinani; Saleh Baeesa; Eman Almuhaini; Ayat Al-Ghafari; Sahar Hakamy; Eyad Faizo; Basem Bahakeem

doi:10.5114/fn.2021.112562

eISSN: 1509-572x
ISSN: 1641-4640

Folia Neuropathologica

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4/2021
vol. 59

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abstract:

Original paper

Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?

Maher Kurdi

¹

,

Heba Alkhatabi

²

,

Nadeem Shafiq Butt

³

,

Hameedah Albayjani

⁴

,

Hessa Aljhdali

⁵

,

Fawaz Mohamed

¹

,

Taghreed Alsinani

⁶

,

Saleh Baeesa

⁷

,

Eman Almuhaini

⁸

,

Ayat B. Al-Ghafari

⁹

,

Sahar Hakamy

⁴

,

Eyad Faizo

¹⁰

,

Basem Bahakeem

¹¹

Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz University, Saudi Arabia

Department of Medical Laboratory Technology, Faculty of Applied Medical Science, King Abdulaziz University, Jeddah, Saudi Arabia

Department of Family and Community Medicine, Faculty of Medicine in Rabigh, King Abdulaziz University, Saudi Arabia

Center of Excellence in Genomic Research, King Abdulaziz University, Jeddah, Saudi Arabia

Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

Department of Surgery, King Fahad General Hospital, Jeddah, Saudi Arabia

Division of Neurosurgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Cancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

10.

Department of Neurosurgery, Tabuk University, Tabuk, Saudi Arabia

11.

Faculty of Medicine, Umm-Alqura University, Makkah, Saudi Arabia

Folia Neuropathol 2021; 59 (4): 350-358

DOI: https://doi.org/10.5114/fn.2021.112562

Online publish date: 2021/12/30

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AMA

Kurdi M, Alkhatabi H, Butt NS, et al. Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?. Folia Neuropathologica. 2021;59(4):350-358. doi:10.5114/fn.2021.112562.

APA

Kurdi, M., Alkhatabi, H., Butt, N. S., Albayjani, H., Aljhdali, H.,  & Mohamed, F. et al. (2021). Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?. Folia Neuropathologica, 59(4), 350-358. https://doi.org/10.5114/fn.2021.112562

Chicago

Kurdi, Maher, Heba Alkhatabi, Nadeem S Butt, Hameedah Albayjani, Hessa Aljhdali, Fawaz Mohamed,  and Taghreed Alsinani et al. 2021. "Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?". Folia Neuropathologica 59 (4): 350-358. doi:10.5114/fn.2021.112562.

Harvard

Kurdi, M., Alkhatabi, H., Butt, N., Albayjani, H., Aljhdali, H., Mohamed, F., Alsinani, T., Baeesa, S., Almuhaini, E., Al-Ghafari, A., Hakamy, S., Faizo, E.,  and Bahakeem, B. (2021). Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?. Folia Neuropathologica, 59(4), pp.350-358. https://doi.org/10.5114/fn.2021.112562

MLA

Kurdi, Maher et al. "Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?." Folia Neuropathologica, vol. 59, no. 4, 2021, pp. 350-358. doi:10.5114/fn.2021.112562.

Vancouver

Kurdi M, Alkhatabi H, Butt N, Albayjani H, Aljhdali H, Mohamed F et al. Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?. Folia Neuropathologica. 2021;59(4):350-358. doi:10.5114/fn.2021.112562.

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Aim of the study
Oligodendrocyte transcriptional factor-2 (Olig2) is an essential marker for oligodendrocytes expression. We aimed to explore the expression of Olig2 in different glial neoplasms and to investigate if diffuse Olig2 expression can replace 1p19q co-deletion for the diagnosis of oligodendroglioma.

Material and methods
Olig2 was performed on 53 samples of different glial neoplasms using immunohistochemistry (IHC). 1p/19q deletions were investigated using fluorescence in situ hybridization (FISH).

Results
Olig2 labelling of different glial neoplasms revealed various expressions, in which 26 tumours showed diffuse expression (≥ 60%) and 23 tumours showed partial focal expression (< 50%). Four tumours showed no expression. Of the 26 tumours, 6 oligodendrogliomas had 1p19q co-deletion and the remaining 3 oligodendrogliomas showed no co-deletion. Three non-oligodendroglial tumours were found to have 19q deletion. The FISH of the remaining tumours (14/26) showed no aberrations. There was no significant difference in the final diagnosis by using 1p19q co-deletion test among glial neoplasms with diffuse Olig2 expression (p = 0.248).

Conclusions
Olig2 marker cannot be used as an alternative diagnostic method for 1p19q co-deletion to distinguish oligodendrogliomas from other glial neoplasms. Although some glial tumours showed diffuse Olig2 expression, 1p19q co-deletion testing is the best diagnostic method.

keywords:

Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?

Maher Kurdi 1 , Heba Alkhatabi 2 , Nadeem Shafiq Butt 3 , Hameedah Albayjani 4 , Hessa Aljhdali 5 , Fawaz Mohamed 1 , Taghreed Alsinani 6 , Saleh Baeesa 7 , Eman Almuhaini 8 , Ayat B. Al-Ghafari 9 , Sahar Hakamy 4 , Eyad Faizo 10 , Basem Bahakeem 11

gliomas, oligodendroglioma, Olig2, FISH, 1p19q co-deletion