Open Access
Issue
Published:
18 September 2020
Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(Ⅱ), Mn(Ⅱ) and Fe(Ⅱ) Theophylline Complexes in Nanoscale
),
Ahmed Mahdi Rheima2(
)
Download citation
405
Views
23
Downloads
12
Crossref
N/A
WoS
23
Scopus
N/A
CSCD
Three nanocomplexes of Zn(Ⅱ), Mn(Ⅱ), Fe(Ⅱ) with theophylline were synthesized by ultrasonic sonication method. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-vis) spectroscopy and C/H/N elemental analyses were used to investigate and suggest the structure of the nanocomplexes. Size and morphology of the nanocomplexes were measurement by transmission electron microscopy (TEM), ranging from 6-22 nm. Efficacy of the nanocomplexes synthesized was examined against four types of bacterial strains: Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria), Klebsiella pneumonia and Escherichia coli (Gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as indicated by their inhibition zones between 98% and 100%.
menu
Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(Ⅱ), Mn(Ⅱ) and Fe(Ⅱ) Theophylline Complexes in Nanoscale
), Ahmed Mahdi Rheima2(
)
Abstract
Three nanocomplexes of Zn(Ⅱ), Mn(Ⅱ), Fe(Ⅱ) with theophylline were synthesized by ultrasonic sonication method. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-vis) spectroscopy and C/H/N elemental analyses were used to investigate and suggest the structure of the nanocomplexes. Size and morphology of the nanocomplexes were measurement by transmission electron microscopy (TEM), ranging from 6-22 nm. Efficacy of the nanocomplexes synthesized was examined against four types of bacterial strains: Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria), Klebsiella pneumonia and Escherichia coli (Gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as indicated by their inhibition zones between 98% and 100%.
References(25)
N.J. Farrer, L. Salassa, P.J. Sadler, Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine. Dalton Transactions. 2009(48): 10690-10701.
C. Garino, L. Salassa. The photochemistry of transition metal complexes using density functional theory. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2013, 71(1995): 20120134.
C. Daniel. Photochemistry and photophysics of transition metal complexes: Quantum chemistry. Coordination Chemistry Reviews. 2015, 282: 19-32.
M. Litecká, R. Gyepes, Z. Vargová, et al., Toxic metal complexes of macrocyclic cyclen molecule-synthesis, structure and complexing properties. Journal of Coordination Chemistry. 2017, 70(10): 1698-1712.
A.H. Ismail, H.K. Al-Bairmani, Z.S. Abbas, et al., Nano-synthesis, spectroscopic characterisation and antibacterial activity of some metal complexes derived from Theophylline. Egyptian Journal of Chemistry. 2020, 63(7): 1-5.
A.M. Rheima, M.A. Mohammed, S.H. Jaber, et al. Adsorption of selenium (Se4+) ions pollution by pure rutile titanium dioxide nanosheets electrochemically synthesized. Desalination and Water Treatment. 2020, 194: 187-193.
A.M. Rheima, M.A. Mohammed, S.H. Jaber, et al., Synthesis of silver nanoparticles using the UV-irradiation technique in an antibacterial application. Journal of Southwest Jiaotong University, 2019, 54(5): 1-11.
A.M. Mohammed, A.M. Rheima, S.H. Jaber, et al., The removal of zinc ions from their aqueous solutions by Cr2O3 nanoparticles synthesized via the UV-irradiation method. Egyptian Journal of Chemistry, 2020, 1: 425-431.
A.M. Rheima, M.A. Mohammed, S.H. Jaber, et al., Inhibition effect of silver-calcium nanocomposite on alanine transaminase enzyme activity in human serum of Iraqi patients with chronic liver disease. Drug Invention Today, 2019, 12(11): 2818-2821.
A.A. Ali, R.M. Al-Hassani, D.H. Hussain, et al., Synthesis, spectroscopic, characterization, pharmacological evaluation, and cytotoxicity assays of novel nano and micro scale of copper (Ⅱ) complexes against human breast cancer cells. Drug Invention Today, 2020, 14(1): 31-39.
D.H. Hussain, A. M, Rheima, and S.H. Jaber., Cadmium ions pollution treatments in aqueous solution using electrochemically synthesized gamma aluminum oxide nanoparticles with DFT study. Egyptian Journal of Chemistry, 2020, 63(2): 417-424.
A.A. Ali, R.M. Al-Hassani, D.H. Hussain, et al., Fabrication of solar cells using novel micro-and nano-complexes of triazole Schiff base derivatives. Journal of Southwest Jiaotong University, 2019, 54(6): 1-19.
A.M. Rheima, D.H. Hussain, and M.M. Almijbilee, Graphene-silver nanocomposite: synthesis, and adsorption study of Cibacron blue dye from their aqueous solution. Journal of Southwest Jiaotong University. 2019, 54(6): 1-8.
D.H. Hussain, H.I. Abdulah, and A.M. Rheima. Synthesis and characterization of γ-Fe2O3 nanoparticles photo anode by novel method for dye sensitized solar cell. International Journal of Scientific and Research Publications. 2016, 6(10): 26-31.
S.H. Jabber, D.H. Hussain, A.M. Rheima, et al., Comparing study of CuO synthesized by biological and electrochemical methods for biological activity. Al-Mustansiriyah Journal of Science, 2019, 30: 94-98.
A.M. Rheima, D.H. Hussain, and H.I. Abdulah, Silver nanoparticles: Synthesis, characterization and their used a counter electrodes in novel Dye sensitizer solar cell. IOSR Journal of Applied Chemistry, 2016, 9: 6-9.
A.H. Ismail, H.K. Al-Bairmani, Z.S. Abbas, et al., Nanoscale synthesis of metal (Ⅱ) theophylline complexes and assessment of their biological activity. Nano Biomed. Eng., 2020, 12(2): 139-147.
T.J. Kistenmacher, D.J. Szalda, and L.G. Marzilli, Intercalative stacking interactions and interligand hydrogen bonding in metal purine complexes. Crystal and molecular structure of (Nsalicylidene-N'-methylethylenediamine)(theophyllinato)copper (Ⅱ) monohydrate. Inorg. Chem., 1975, 14: 1686-1691.
E. H. Hamdani, E. Amane, and C. Duhayon. Crystal structure of tetraaquabis (1, 3-dimethyl-2, 6-dioxo-7H-purin-7-ido-κN7) cobalt (Ⅱ). Acta Crystallographica Section E: Crystallographic Communications. 2017, 73(9): 1302-1304.
J. Lorberth, W. Massa, E. Essawi, et al., Trimethylplatinum-theophylline hexamer: A novel Pt6 heterocycle containing both Pt- N and Pt- O bonds. Angewandte Chemie International Edition in English, 1988, 27(9): 1160-1161.
M. Gacki, K. Kafarska, A. Pietrzak, et al., Synthesis, characterisation, crystal structure and biological activity of metal (Ⅱ) complexes with theophylline. Journal of Saudi Chemical Society, 2019, 23(3): 346-354.
M.S. Refat, H.K. Ibrahim, S.Z. Sowellim, et al., Spectroscopic and thermal studies of Mn(Ⅱ), Fe(Ⅲ), Cr(Ⅲ) and Zn(Ⅱ) complexes derived from the ligand resulted by the reaction between 4-Acetyl Pyridine and Thiosemicarbazide. Journal of Inorganic and Organometallic Polymers and Materials, 2009, 19(4): 521.
Publication history
Copyright
Acknowledgements
This work was supported by Department of Chemistry, College of Science, Mustansiriyah University.
Rights and permissions
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
FEEDBACK 
TOP