Place cells of the rodent hippocampus fire action potentials when the animal traverses a particular spatial location in any environment. Therefore for any given trajectory one observes a repeatable sequence of place cell activations. When the animal is quiescent or sleeping, one can observe similar sequences of activation known as replay, which underlie the process of memory consolidation. However, it remains unclear how replay is generated. Here we show how a temporally asymmetric plasticity rule during spatial exploration gives rise to spontaneous replay in a model network by shaping the recurrent connectivity to reflect the topology of the learned environment. Crucially, the rate of this encoding is strongly modulated by ongoing rhythms. Oscillations in the theta range optimize learning by generating repeated pre-post pairings on a time-scale commensurate with the window for plasticity, while lower and higher frequencies generate learning rates which are lower by orders of magnitude.
Rat A991 on novel square track w muscimol
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel square track, medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
Yingxue Wang - A991-20140826-02_BehavElectrDataLFP_muscimol.mat
Rat A991 on square track post-muscimol
Matlab file with multi-unit, lfp and animal position. 35 min exploration of square track after animal recovered from medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
A991-20140826-04_BehavElectrDataLFP.mat
Rat A992 on novel square track w muscimol
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel square track, medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
Yingxue Wang - A992-20140824-01_BehavElectrDataLFP_muscimol.mat
Rat A992 on square track post-muscimol
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel square track after recovery from medial septum inactivated by muscimol. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
A992-20140824-03_BehavElectrDataLFP.mat
Rat A991 on novel hexagonal track
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 1. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
A991-20140830-01_BehavElectrDataLFP.mat
Rat A991 on novel hexagonal track (2nd session)
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 2. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
Yingxue Wang - A991-20140830-03_BehavElectrDataLFP.mat
Rat A991 on novel hexagonal track (3rd session)
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 3. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
A991-20140830-05_BehavElectrDataLFP.mat
Rat A992 on novel hexagonal track
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 1. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
A992-20140831-01_BehavElectrDataLFP.mat
Rat A992 on novel hexagonal track (2nd session)
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 2. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
Yingxue Wang - A992-20140831-03_BehavElectrDataLFP.mat
Rat A992 on novel hexagonal track (3rd session)
Matlab file with multi-unit, lfp and animal position. 35 min exploration of novel hexagonal track: session 3. From Pastalkova lab at Janelia Research Campus, data collected by Yingxue Wang.
A992-20140831-05_BehavElectrDataLFP.mat