Since the discovery of anti-leprotic agents such as Sulfone, long acting Sulfamine, Antibiotics and Thiourea etc., other new drugs have been studied in respect to theiranti-leprotic activity.
The thiourea family drugs have been applied in leprosy by many authors, all reporting good results. The chemical structural formula of thiourea and thiosemicar-bazide are exactly like each other. There-fore, the author has expected good effect to treatment of leprosy by thiosemicarbazide drugs. On this idea, the author has synthesed new some of compounds as follow.DOT OH NH CS NHN=CH N CH3CH3 Methoxy-DOT CH3O NH CS NHN=CH N CH3CH3 Ethoxy-DOT C2H5O NH CS NHN=CH N CH3CH3 These compounds have proved antibacterial action (H37RV) in 70, 000 100, 000 times diluted solutions, and these toxicity was very little in experiment.
Accordingly, the author believes these compounds can be used to application forclinic of leprosy or tuberculosis.