Numerous complicated and diverse genetic variables that are heterogeneous all contribute to cardiomyopathy. Depending on the definition and location, different areas have different rates of cardiomyopathy. Cardiovascular disease is the most common inherited cause of cardiomyopathy. Other variables that contribute to the progression of cardiomyopathy include coronary heart disease and high blood pressure. The investigation of the relationship between cardiomyopathy and its genetic variations with biomarker is the major goal of this study. The pathophysiology and development of cardiomyopathy are significantly influenced by a few new genes linked to human hereditary cardiomyopathy. Human gene mutations and data compiled from several databases have revealed that various genes have been linked to cardiomyopathy, explaining the susceptibility of the illness. Our findings contribute to a better understanding of the genetic component with biomarker of cardiomyopathy and will help to better understand how the disease mode influences prognosis. Furthermore, improved understanding of molecular pathophysiology of genetic cardiomyopathy may open the framework for the growth of personalized therapies in the future. A structural or functional abnormality of the myocardium is a hallmark of cardiomyopathies, which are heart disorders. There are several kinds and sub kinds, some of which have a significant genetic component. Medical and genetic advancements have improved our understanding of cardiomyopathies. This article discusses the classification, pathogenesis, and biomarker presentation of the major cardiomyopathies.