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    Korean J Urol. 2007 Nov;48(11):1104-1108. Korean.
    Published online Nov 30, 2007.
    https://doi.org/10.4111/kju.2007.48.11.1104
    Copyright © 2007 The Korean Urological Association
    Original Article

    Prognosis of Transitional Cell Carcinoma of the Bladder in Patients 40 Years Old or Less: Comparison with Elderly Patients

    Ki Hoon Kim, Sun Il Kim and Se Joong Kim
      • Department of Urology, Ajou University School of Medicine, Suwon, Korea.
    • Corresponding author (Email: sejoong@ajou.ac.kr )
    Received August 01, 2007; Accepted August 29, 2007.

    Abstract

    Purpose

    The natural history and prognosis of transitional cell carcinoma (TCC) of the bladder in young patients remain a matter of debate. This study aimed to evaluate whether TCC of the bladder in young patients is biologically different from that found in elderly patients.

    Materials and Methods

    The medical records of 21 patients presenting with TCC of the bladder at 40 years of age and younger (group 1) were reviewed and compared with those of 94 patients who were diagnosed with bladder TCC at 51 years of age and older (group 2).

    Results

    The initial stage distribution was similar with 85.7% and 79.8% of patients presenting with superficial TCC in group 1 and 2, respectively. The gross hematuria as a presenting symptom, multiplicity of tumor mass, T stage, N stage, M stage, concomitant carcinoma in situ (CIS) and grade were not significantly different between the two groups. There was no difference in the cancer-specific survival rate between the two groups. For the cases with superficial TCC, no difference was observed in the disease-free survival rate or progression-free survival rate between the two groups.

    Conclusions

    TCC of the bladder in patients 40 years old or less has a similar clinicopathological distribution and disease outcome to those observed in elderly patients. It is suggested that the management and follow-up of TCC of the bladder in young patients should be the same as those for elderly patients.

    Keywords
    Urinary bladder neoplasms; Transitional cell carcinoma; Age factors; Prognosis

    Figures

    Fig. 1
    Kaplan-Meier cancer-specific survival curves showed that there was no difference in the survival rate between the two groups (p=0.905).

    Fig. 2
    Kaplan-Meier disease-free survival curves in patients with superficial bladder cancer. No difference was observed in the survival rate between the two groups (p=0.821).

    Fig. 3
    Kaplan-Meier progression-free survival curves in patients with superficial bladder cancer. No difference was observed in the survival rate between the two groups (p=0.595).

    Tables

    Table 1
    Comparison of the clinical characteristics between young and elderly patients

    Table 2
    Comparison of the clinicopathological variables of bladder cancer between young and elderly patients

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    MeSH Terms
    Adult*
    Age Factors
    Aged*
    Carcinoma, Transitional Cell*
    Disease-Free Survival
    Follow-Up Studies
    Hematuria
    Humans
    Medical Records
    Natural History
    Prognosis*
    Survival Rate
    Urinary Bladder Neoplasms
    Urinary Bladder*
    Metrics
    Share
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