Prevention of Tissue Adhesion by a Spontaneously Formed Phospholipid Polymer Hydrogel

Mizuna Kimura; Tomohiro Konno; Madoka Takai; Noriyuki Ishiyama; Toru Moro; Kazuhiko Ishihara

doi:10.4028/www.scientific.net/KEM.342-343.777

Paper Titles

Effect of Different Hydroxyapatite Particles on Malignant Melanoma Cell Behavior
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Effect of Hydroxyapatite-Tricalcium Phosphate Micro-Particles on the Cellular Interaction of In Situ Hyaluronic Acid-Poly(Ethylene Oxide) Hydrogel
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The Study of Human Epithelium Cell Attachment to the Surface of Anode-Oxidized Titanium
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Effects of Herbal Extracts on Dental Plaque Formation and Human Gingival Fibroblasts
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Prevention of Tissue Adhesion by a Spontaneously Formed Phospholipid Polymer Hydrogel
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Degradation Control of Collagen by Epigallocatechin-3-O-Gallate
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Adhesion to Cells of Enzyme Conjugated Phospholipid Polymer Nanoparticles
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Surface Modification by Grafting with Biocompatible 2-Methacryloyloxyethyl Phosphorylcholine for Microfluidic Devices
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Surface Modification of Magnetite Nanoparticles with Doxorubicin and RGD Peptide and their Biomedical Application
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Prevention of Tissue Adhesion by a Spontaneously Formed Phospholipid Polymer Hydrogel

Abstract:

We investigated phospholipid polymer hydrogels containing Fe3+ ions (PMA/PMB/Fe hydrogel) for their use as antiadhesive materials in the healing tissues. These hydrogels were prepared from the aqueous solutions of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-comethacrylic acid) (PMA) and poly(MPC-co-n-butyl methacrylate) (PMB). The PMA/PMB hydrogel is formed by the intermolecular interactions between PMA and PMB, and it reversibly dissociates under physiological conditions. The addition of Fe3+ ions could control the gelation time and the dissociation time. Mechanical properties such as the gelation time and viscoelastic properties can be controlled by the FeCl3 concentration. With regard to biocompatibility, no evidence of inflammation was observed in vivo. Therefore, the PMA/PMB/Fe hydrogel has a potential to be used as an antiadhesive material.