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HomeAdvances in Science and TechnologyAdvances in Science and Technology Vol. 53Folic Acid Immobilized Ferrimagnetic DP-Bioglass...

Folic Acid Immobilized Ferrimagnetic DP-Bioglass to Target Tumor Cell for Cancer Hyperthermia Treatment

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Abstract:

DP-bioglass is one of biodegradable glasses, which can be used as bioactive material in soft tissue and bone. It was often used in orthopedy and plastic surgery. Recently, bioglass was also used as a carrier for drug and gene delivery systems. Additionally, ferrimagnetic DP-bioglass can be potential candidates for magnetic induction hyperthermia, by using a magnetic field. The aim of this work is the preparation and characterization of surface-modified ferrimagnetic DP-bioglass. First DP-bioglass has to be surface-modified with polyethylene glycol (PEG) and folic acid (FA) to improve its intracellular uptake and ability to target specific cells. PEG-FA complex was synthesized using carbodiimide (DCC) to link PEG with FA. Then PEG-FA complex were immobilized on the surface of DP-bioglass by using amino-silane (AEAPS) as a coupling agent. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1H NMR), and thermogravimetric analysis (TGA) was used to demonstrate this immobilization process. In biological study showed that immobilized ferromagnetic DP-bioglass with PEG-FA was non-cytotoxicity and significantly enhanced the intracellular uptake of DP-bioglass by target cells.

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Periodical:

Advances in Science and Technology (Volume 53)

Pages:

50-57

DOI:

https://doi.org/10.4028/www.scientific.net/AST.53.50

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Online since:

October 2006

Authors:

Min Hua Chen, Chung King Hsu, Feng Huei Lin, Leszek Stobinski, Jerzy Peszke

Keywords:

DP-Bioglass, Ferrimagnetic, Folic Acid, Immobilisation, Polyethylene Glycol (PEG)

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[1] A. Ito, M. Shinkai, H. Honda, T. Kobayashi: J. Biosci. Bioengi. Vol. 100 (2005), pp.1-11.

[2] A. K. Gupta, M. Gupta: Biomat. Vol. 26 (2005), pp.3995-4021.

[3] O. Bretcanu, E. Vernè: 2005 NSTI Nanotech. Confer. & Trade Show.

[4] B. Le, M. Shinkai, T. Kitada: J. Chem. Engi. Jap. Vol. 34 (2001), pp.66-72.

[5] M. Shinkai, B. Le, H. Honda: Jap. J. Cancer Res. Vol. 92 (2001), pp.1138-1145.

[6] T. Emery, Iron and Your Health: Facts and Fallacies, CRC Press Inc, (1991).

[7] N. Heybeli, F. N. Oktar, S. Ozyazgan: Tech. Heal. Care Vol. 11 (2003), pp.207-216.

[8] F. H. Lin, C. C. Lin, H. C. Liu: Bioma. Vol. 15 (1994), pp.1087-1098.

[9] T. Leventouri, A. C. Kis, J. R. Thompson: Bioma. Vol. 26 (2005), pp.4924-4931.

[10] D. Arcos, R. P. D. Real, M. V. Regi, A novel and magnetic biphasic material, Biomaterials, vol. 23, 2002, pp.2151-2158.

DOI: 10.1016/s0142-9612(01)00346-5

[11] J. M. Harris: New York: Plenum Press, 1992, pp.1-14.

[12] A. Gabizon, H. Shmeeda, A. T. Horowitz: Adv. Drug Deli. Rev. Vol. 56 (2004).

[13] Y. Zhang, J. Zhang: J. Col. Inter. Sci. Vol. 283 (2005), pp.352-357.

[14] E. Khor: Biomaterials Vol. 18 (1997), pp.95-105.

[15] R. J. Lee, P. S. Low: Biochi. et Bioph. Acta Vol. 1233 (1995), pp.134-144.

[16] X. Liu, Z. Ma, J. Xing: J. Magn. Magn. Mat. Vol. 270 (2004), pp.1-6.

[17] M. Ma, Y. Zhang, W. Yu: Coll. Sur. A: Physi. Engi. Asp. Vol. 212 (2003), pp.219-226.

[18] X. Liu, J. Xing, Y. Guan: Coll. Sur. A: Physi. Engi. Asp. Vol. 238 (2004), pp.127-131.

[19] Y. Zhang, N. Kohler, M. Zhang: Bioma. Vol. 23 (2002), pp.1553-1561.

[20] Promega: Medison, Promega Corporation, Technical Buletin.

[21] Takara, Premix WST-1 cell proliferation assay system, Takara, Cat. # MK400.

[22] N. W. Kohler, G. E. Fryxell, M. Zhang: J. Ame. Che. Soci. Vol. 126 (2004), pp.7206-7211.

[23] P. V. Paranjpe, Y. Chen, V. Kholodovych: J. Contr. Rel. Vol. 100 (2004), pp.275-292.

[24] J. Zhong, D. C. Greenspan: J. Biome. Mat. Res. Vol. 53 (2000), pp.694-701.

[25] Z. Demjen, B. Pukanszky, J. N. Jr: Polymer Vol. 40 (1999), pp.1763-1773.

[26] J. G. Benito, J. Coll. Inter. Sci. Vol. 267 (2003), pp.326-332.

[27] F. H. Lin, C. H Yao, J. S. Sun: Bioma. Vol. 19 (1998), pp.905-917.

[28] Y. Ebisawa, F. Miyaji, T. Kokubbo: Bioma. Vol. 18 (1997), pp.1277-1284.