Preparation and Characterization of mPEG Modified Magnetic Long-Circulating Doxorubicin Hydrochloride Liposomes

Yu Fang; Xiu Gen Wu; Jin Chen; Sheng Chun Dang; De Li Jiang; Min Chen; Ji Min Xie

doi:10.4028/www.scientific.net/AMR.661.87

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 661Preparation and Characterization of mPEG Modified...

Preparation and Characterization of mPEG Modified Magnetic Long-Circulating Doxorubicin Hydrochloride Liposomes

Abstract:

In this work, long-circulating doxorubicin hydrochloride (Doc) liposomes were prepared by the of ammonium sulphate gradients with ethanol injection, and the methoxy polyethylene glycol (mPEG) was added to modify the membrane property of the liposomes. The long-circulating mPEG-modified Doc liposomes were nearly round with a particle size ranging from 50 to 70 nm. The entrapment efficiency of Doc was determined to be 57.53 %. Meanwhile, the experiment results indicated that the long-circulating Doc liposomes show good sustained release property.

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Periodical:

Advanced Materials Research (Volume 661)

Pages:

87-90

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.661.87

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Online since:

February 2013

Authors:

Yu Fang, Xiu Gen Wu, Jin Chen, Sheng Chun Dang, De Li Jiang, Min Chen, Ji Min Xie

Keywords:

Doxorubicin Hydrochloride, Long-Circulating, Magnetic Liposome

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