Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as Intermediate for Montelukast Sodium

Shu An Li; Run Lai Li; Zhen Ming Zhang; Sheng Ye; Guo Cheng Wang; Hang Hang Liu

doi:10.4028/www.scientific.net/AMR.641-642.7

Paper Titles

Comparative Researches on Two Kinds of Staining Method of Acetylcholinesterase Isozymes
p.3

Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as Intermediate for Montelukast Sodium
p.7

The Photocatalytic Properties of Br-Doped Titania Nanotube Arrays and its Application in Degradation of Sugar Wastewater
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Response of Antioxidant System in Leaves of Ginkgo biloba to Elevated CO₂ and/or O₃ and its Natural Recovery in an Urban Area
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Photosynthetic Responses of Four Urban Tree Species Exposed to Elevated CO₂ and/or Elevated O₃
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Effect of Coal Dust on Coalbed Methane Wells Productivity
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Heterogeneous Fenton System Dynamic Decolorization of Simulated Dye Wastewater
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Action of Flow Rate of Mobile Phase in Chromatography
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 641-642Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as...

Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as Intermediate for Montelukast Sodium

Abstract:

1,1-Bis(hydroxymethyl)cyclopropane was synthesized by reaction dibromoneopentyl glycol with zinc powder at mole ratio of nDG:nzinc=1:1.05 and 80oC (slightly reflux) for 7 hours. Under optimal conditions, yield and purity of the title compound were 87.3% and 98.67%, respectively. Dibromoneopentyl glycol was also prepared in 91.7% yield with pentaerythritol and hydrobromic acid as material and diethyl sulfate as catalyst under reflux for 10 hours. Structural characterization of 1,1-bis(hydroxymethyl)cyclopropane was conducted by IR and H-NMR.

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Periodical:

Advanced Materials Research (Volumes 641-642)

Pages:

7-10

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.641-642.7

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Online since:

January 2013

Authors:

Shu An Li, Run Lai Li, Zhen Ming Zhang, Sheng Ye, Guo Cheng Wang, Hang Hang Liu

Keywords:

1,1-Bis(hydroxymethyl)cyclopropane, Intermediate, Montelukast Sodium, Synthesis

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