Synthesis, Characterization and Neurotoxicity Screening of Schiff Base Ligands and their Complexes

Ahmad Fauzi Abu Bakar; Hadariah Bahron; Karimah Kassim

doi:10.4028/www.scientific.net/AMR.554-556.938

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 554-556Synthesis, Characterization and Neurotoxicity...

Synthesis, Characterization and Neurotoxicity Screening of Schiff Base Ligands and their Complexes

Abstract:

Two ligands and four complexes are successfully synthesized by reacting 1,8-diaminonapthelene with aldehyde/ketone derivatives in ratio amine:aldehyde/ketone (1:2) for ligands formation and 1:1 ratio (ligand:metals) for complexes formation. The compounds were characterized through CHNS elemental analysis, IR spectroscopy, 1H NMR spectroscopy, melting point determination, and magnetic susceptibility determination. The neurotoxicity screening of compounds was screened using neuroblastoma SH-SY5Y cell lines and it was indicate the cells were non-toxic either for ligands and complexes after 24 hours exposure.

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Periodical:

Advanced Materials Research (Volumes 554-556)

Pages:

938-943

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.554-556.938

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Online since:

July 2012

Authors:

Ahmad Fauzi Abu Bakar, Hadariah Bahron, Karimah Kassim

Keywords:

1,8-Diaminonaphthalene, Neurotoxicity Screening, Schiff-Base, SH-SY5Y Neuroblastoma Cell Lines

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