Study on Texture Features of Cingulum in Different Gender Patients with Alzheimer’s Disease and Mild Cognitive Impairment Based on MR Images

Article Preview

Abstract:

The aim of this article is to study the texture features of cingulum in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) based on magnetic resonance images, and explore the texture differences derived from different gender among each group. Texture analysis was performed on 7 AD patients, 14 MCI patients and 11 normal controls (NC). Texture features extracted from gray level co-occurrence matrix and run-length matrix were analyzed between each two groups. The results showed that texture features of the anterior cingulum had significant differences in the multiple comparisons and features of the posterior cingulum had significant differences between AD and MCI group as well as AD and NC group. There were significant differences between AD and MCI group as well as AD and NC group in male’s cingulum. While in female’s cingulaum, the differences were founded between AD and NC group. The results indicated that the pathological changes in cingulum could be reflected by texture features and the pathological changes may be different in the two genders.

You might also be interested in these eBooks

Info:

Periodical:

Advanced Materials Research (Volumes 301-303)

Pages:

1060-1065

Citation:

Online since:

July 2011

Export:

Price:

[1] WM van der Filer, P. Scheltens: Epidemiology and risk factors of dementia. Journal of Neurology, Neurosurgery & Psychiatry, 2005, 76: 2-7.

Google Scholar

[2] P.J. Visser: Principles and Practice of Geriatric Medicine, 4th Edition, edited by M.S. John Pathy, Alan J. Sinclair and John E. Morley, John Wiley & Sons, Ltd (2006).

Google Scholar

[3] G. Pengas, J.R. Hodges, P. Watson and P.J. Nestor: Focal posterior cingulate atrophy in incipient Alzheimer's disease. Neurobiology of Aging, 2010, 31: 25-33.

DOI: 10.1016/j.neurobiolaging.2008.03.014

Google Scholar

[4] IL.H. Choo, D.Y. Le, J.S. Oh, J.S. Lee, D.S. Lee, I.C. Song, J.C. Youn, S.G. Kim, K.W. Kim, J.H. Jhoo and J.I. Woo: Posterior cingulate cortex atrophy and regional cingulum disruption in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging, 2010, 31: 772-779.

DOI: 10.1016/j.neurobiolaging.2008.06.015

Google Scholar

[5] XJ Guo, ZQ Wang, KC Li, ZY Li, ZG Qi, Z Jin, L Yao, KW Chen: Voxel-based assessment of gray and white matter volumes in Alzheimer's disease. Neuroscience Letters, 2010, 468: 146-150.

DOI: 10.1016/j.neulet.2009.10.086

Google Scholar

[6] FL Giesel, HK Hahn, P.A. Thomann, E. Widjaja, E. Wignall, H. von Tengg-Kobligk, J. Pantel, P.D. Griffiths, H.O. Peitgen, J. Schroder and M. Essig: Temporal horn index and volume of medial temporal lobe atrophy using a new semiautomated method for rapid and precise assessment. American Journal of Neuroradiology, 2006, 27: 1454-1458.

Google Scholar

[7] M. Muskulus, A.E. Scheenstra, N. Braakman, J. Dijkstra, S. Verduyn-Lunel, A. Alia, H.J. de Groot and J.H. Reiber: Prospects for early detection of Alzheimer's disease from serial MR images in transgenic mice [J]. Current Alzheimer Research, 2009, 6(6): 503-518.

DOI: 10.2174/156720509790147089

Google Scholar

[8] R. Vassar: Beta-Secretase, APP and Abeta in Alzheimer's disease. Subcell Biochem, 2005, 38: 79-103.

Google Scholar

[9] GL Jiang,X Li,SF Li and LZ Tong: Texture Analysis of Corpus Callosum and Cingulate on Magnetic Resonance Image in Patients with Alzheimer'S Disease. Beijing Biomedical Engineering, 2010, 29(2): 131-134.

Google Scholar

[10] M.M. Mielke, N.A. Kozauer, K.C.G. Chan, M. George, J. Toroney, M. Zerrate, K. Bandeen-Roche, M. -C. Wang, P. vanZijl, J.J. Pekar, S. Mori, C.G. Lyketsos and M. Albert: Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. NeuroImage, 2009, 46: 47-55.

DOI: 10.1016/j.neuroimage.2009.01.054

Google Scholar

[11] C. Plant, S.J. Teipel, A. Oswald, C. Böhm, T. Meindl, J. Mourao-Miranda, A.W. Bokde, H. Hampel and M. Ewers: Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease. NeuroImage, 2010, 50: 162-174.

DOI: 10.1016/j.neuroimage.2009.11.046

Google Scholar

[12] G. Catheline, O. Periot, M. Amirault, M. Braun, Jean-Franc¸ois Dartigues, S. Auriacombe and M. Allard: Distinctive alterations of the cingulum bundle during aging and Alzheimer's disease. Neurobiology of Aging, 2010, 31: 1582-1592.

DOI: 10.1016/j.neurobiolaging.2008.08.012

Google Scholar

[13] N.A. Azad, M. AI. Bugami and I. Loy-English: Gender differences in dementia risk factors. GENDER MEDICIN, 2007, 4: 120-129.

DOI: 10.1016/s1550-8579(07)80026-x

Google Scholar

[14] X. Hua, D.P. Hibar, S. Lee, A.W. Toga, C.R. Jack Jr., M.W. Weiner and P.M. Thompson: Sex and age differences in atrophic rates: an ADNI study with n=1368 MRI scans. Neurobiology of Aging, 2010, 31: 1463-1480.

DOI: 10.1016/j.neurobiolaging.2010.04.033

Google Scholar

[15] K. Menzler, M. Belke, E. Wehrmann, K. Krakow, U. Lengler, A. Jansen, H.M. Hamer, W.H. Oertel, F. Rosenow and S. Knake: Men and women are different: Diffusion tensor imaging reveals sexual dimorphism in the microstructure of the thalamus, corpus callosum and cingulum. NeuroImage, 2011, 54: 2557-2562.

DOI: 10.1016/j.neuroimage.2010.11.029

Google Scholar