Design and Manufacturing of Drug Eluting Depot Stents with Micro-Sized Drug Reservoirs

Hao Ming Hsiao; Chun Ting Yeh; Tsung Yuan Wu; Li Wei Wu; Bor Hann Huang; Hsiao Nan Yang

doi:10.4028/www.scientific.net/AMM.479-480.225

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 479-480Design and Manufacturing of Drug Eluting Depot...

Design and Manufacturing of Drug Eluting Depot Stents with Micro-Sized Drug Reservoirs

Abstract:

The effects of micro-sized through-hole drug reservoirs on several key clinical attributes of the drug eluting depot stent were investigated. Finite element models were developed to predict the mechanical integrity of a balloon-expandable stent at various stages such as manufacturing and deployment, as well as the stent radial strength and fatigue life. Results show that (1) creating drug reservoirs on a stent could impact the stent fatigue resistance to certain degrees, and (2) drug reservoirs on the stent crowns led to much greater loss in all key clinical attributes than reservoirs on other locations. Based on these findings, an optimized depot stent was proposed/manufactured and proven to be a feasible design.

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Periodical:

Applied Mechanics and Materials (Volumes 479-480)

Pages:

225-229

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.479-480.225

Citation:

Cite this paper

Online since:

December 2013

Authors:

Hao Ming Hsiao, Chun Ting Yeh, Tsung Yuan Wu, Li Wei Wu, Bor Hann Huang, Hsiao Nan Yang

Keywords:

Depot Stent, Drug Reservoir, Drug-Eluting Stent, Key Clinical Attributes, Stent Fatigue Life

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References

[1] M. Morice, P.W. Serruys, J.E. Sousa, J. Fajadet, E.B. Hayashi, M. Perin, A. Colombo, G. Schuler, P. Barragan, G. Guagliumi, F. Molnar, R. Falotico, A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization, N. Engl. J. Med. 346 (2002).

DOI: 10.1056/nejmoa012843

Google Scholar

[2] A. Finkelstein, D. McClean, S. Kar, K. Takizawa, K. Varghese, N. Baek, K. Park, M.C. Fishbein, R. Makkar, F. Litvack, N.L. Eigler, Local drug delivery via a coronary stent with programmable release pharmacokinetics, Circulation. 107 (2003).

DOI: 10.1161/01.cir.0000050367.65079.71

Google Scholar

[3] P.W. Serruys, G. Sianos, A. Abizaid, J. Aoki, P. den Heijer, H. Bonnier, P. Smits, D. McClean, S. Verheye, J. Belardi, J. Condado, M. Pieper, L. Gambone, M. Bressers, J. Symons, E. Sousa, F. Litvack, The effect of variable dose and release kinetics on neointimal hyperplasia using a novel paclitaxel-eluting stent platform - The paclitaxel in-stent controlled elution study (PISCES), J. Am. Coll. Cardiol. 46 (2005).

DOI: 10.1016/j.jacc.2005.03.069

Google Scholar

[4] H.M. Hsiao, A. Nikanorov, S. Prabhu, M.K. Razavi, Respiration-induced kidney motion on cobalt-chromium stent fatigue resistance, J. Biomed. Mater. Res. Part B, 91B (2009) 508-516.

DOI: 10.1002/jbm.b.31424

Google Scholar

[5] H.M. Hsiao, Y.H. Chiu, K.H. Lee, C.H. Lin, Computational modeling of effects of intravascular stent design on key mechanical and hemodynamic behavior, Comput. Aided Design. 44 (2012) 757-765.

DOI: 10.1016/j.cad.2012.03.009

Google Scholar