1993 Volume 54 Issue 9 Pages 2224-2228
The expression of epidermal growth factor (EGF) in terms of proliferation and progress of the tumors was immunohistochemically studied in 94 resected gastric carcinomas by using anti-human EGF antibody. EGF were predominantly expressed in carcinomas of type, ps(+), and in stage III or IV. EGF expression was associated with high incidence of lymph node metastasis. In the carcinomas of C lesion of the stomach, the ratio of EGF(+) cases was higher in poorly differentiated type than in well differentiated type. Five year survival rate of the cases with EGF(+) carcinoma had lower than of EGF(-) cases. These results suggested that expression of EGF could be a valuable marker for predicting prognosis of patients with gastric carcinoma.
