Postoperative (adjuvant) chemothrapy with 5-fluorouracil (5-FU) and cisplatin (CDDP) has been shown to prolong the survaival time in patients with advanced gastric cancer. A series of 32 patients with gastric cancer with paraaortic lymph nodes metastasis whose peritoneal dissemination was limited to P0 or P1 and hepatic metastasis to H0 or H1 were experienced in a recent 6-year period from January 1990 to December 1996. Of these 32 patients. 14 patients were assigned to the postoperative combination chemotherapy group and the remaining 18 patients were served as control, and two groups were compared for postoperative survival time. Five hundred mg/body/day of 5-FU was continuously administered via venus catheter for 5 days and 5 or 10mg/body/day of CDDP was rapidly administered with 100 ml saline on days 1_??_5. The survival period was prolonged in the 14 patients who underwent surgery plus continuous 5-FU and low dose (daily) CDDP compared with the control patients (p<0.05). The 50% survival duration of the combination therapy group was 19 months versus 9 months in the control group. Adverse side effects included leukopenia, thrombocytopenia, nausea, appetite loss and general fatigue; these were not life-threatening and did not requirer interruption of the therapy. Continuous 5-FU and low dose (dairy) CDDP therapy combined with extensive surgery provides an effective and practical method of treating this disease entity.