Robotic Radical Prostatectomy at the Egyptian National Cancer Institute: Overcoming the Challenges in the Initial Case Series

Authors

  • Ashraf Zaghloul Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
  • Ahmed Abdelbary Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt https://orcid.org/0000-0001-5240-8532
  • Amr Fergany Consulting Urologist, Sebastian River Medical Center, Florida, USA
  • Hatem Aboulkassem Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt
  • Waleed Mohamed Fadlalla Department of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2021.6107

Keywords:

Robotic surgical procedures, Learning curve, Technical difficulties, Re-docking, Robotic to open conversion, Operative time

Abstract

BACKGROUND: Robotic prostatectomy is showing progressive worldwide spread owing to potential clinical benefits, but at a higher cost.

AIM: This article describes the challenges and clinical outcomes of the first group of patients undergoing robotic prostatectomy in Egypt.

DESIGN, SETTING, PARTICIPANTS: From 2017 to 2019, the data of all (55) patients undergoing robotic radical prostatectomy at the National Cancer Institute of Egypt were retrospectively analyzed.

OUTCOME EVALUATION: Short-term operative outcomes, complications, technical difficulties, pathologic data, and biochemical recurrence were reported.

RESULTS: Average blood loss was 296 ml; one patient required blood transfusion. One case required open conversion, another required re-docking of the robot. Setup time was significantly improved from an average of 27.7 min in the first 27 cases to an average of 17.3 min in the final 28 cases (p < 0.0001). Complications developed in 27% of our patients. Continence recovery at catheter removal, 1st, 3rd, 6th, and 12th months were 32.7%, 50.9%, 65.5%, 74.5%, and 96%, respectively.

CONCLUSIONS: Results from the first series of robotic radical prostatectomy were encouraging. Technical challenges can be overcome in a short period using a dedicated team supplemented by institutional support. Acceptable complication rate and satisfactory outcomes regarding continence and blood loss were observed.

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References

Ibrahim AS, Khaled HM, Mikhail NN, Baraka H, Kamel H. Cancer incidence in Egypt: Results of the national population-based cancer registry program. J Cancer Epidemiol. 2014;2014:437971. https://doi.org/10.1155/2014/437971 PMid:25328522 DOI: https://doi.org/10.1155/2014/437971

Gretzer MB, Trock BJ, Han M, Walsh PC. A critical analysis of the interpretation of biochemical failure in surgically treated patients using the American society for therapeutic radiation and oncology criteria. J Urol. 2002;168(4):1419-22. https://doi.org/10.1016/s0022-5347(05)64464-3 PMid:12352408 DOI: https://doi.org/10.1016/S0022-5347(05)64464-3

Bianco FJ, Scardino PT, Eastham JA. Radical prostatectomy: Long-term cancer control and recovery of sexual and urinary function (“trifecta”). Urology. 2005;66 Suppl 5:83-94. https://doi.org/10.1016/j.urology.2005.12.053 PMid:16194712 DOI: https://doi.org/10.1016/j.urology.2005.06.116

Cathelineau X, Arroyo C, Rozet F, Baumert H, Vallancien G. Laparoscopic radical prostatectomy: The new gold standard? Curr Urol Rep. 2004;5(2):108-14. https://doi.org/10.1007/s11934-004-0022-x PMid:15028202 DOI: https://doi.org/10.1007/s11934-004-0022-x

Kolata G. Results Unproven, Robot Surgery Wins Converts, New York Times; 2010. p. A1.

Elawdy MM. Robotic surgery: A mini-review from a middle eastern perspective. Ely J Uro. 2017;1(1):103.

Zargar-Shoshtari K, Murphy DG, Zargar H. Re: Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: Early outcomes from a randomised controlled phase 3 study. Eur Urol. 2017;71(1):140-1. https://doi.org/10.1016/j.eururo.2016.09.016 PMid:27641790 DOI: https://doi.org/10.1016/j.eururo.2016.09.016

Matanes E, Boulus S, Lowenstein L. The implementation of robotic surgery in Israel. Isr Med Assoc J. 2015;17(9):563-6. PMid:26625547

Menon M, Tewari A, Peabody JO, Shrivastava A, Kaul S, Bhandari A, et al. Vattikuti Institute prostatectomy, a technique of robotic radical prostatectomy for management of localized carcinoma of the prostate: Experience of over 1100 cases. Urol Clin North Am. 2004;31(4):701-17. https://doi.org/10.1016/j.ucl.2004.06.011 PMid:15474597 DOI: https://doi.org/10.1016/j.ucl.2004.06.011

Guillonneau B, Vallancien G. Laparoscopic radical prostatectomy: The Montsouris technique. J Urol. 2000;163(6):1643-9. https://doi.org/10.1016/s0022-5347(05)67512-x PMid:10799152 DOI: https://doi.org/10.1016/S0022-5347(05)67512-X

Dindo D, Demartines N, Clavien PA. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. https://doi.org/10.1097/01.sla.0000133083.54934.ae PMid:15273542 DOI: https://doi.org/10.1097/01.sla.0000133083.54934.ae

Gratzke C, Dovey Z, Novara G, Geurts N, De Groote R, Schatteman P, et al. Early catheter removal after robot-assisted radical prostatectomy: Surgical technique and outcomes for the Aalst technique (ECaRemA Study). Eur Urol. 2016;69(5):917-23. https://doi.org/10.1016/j.eururo.2015.09.052 PMid:26578444 DOI: https://doi.org/10.1016/j.eururo.2015.09.052

Korets R, Weinberg AC, Alberts BD, Woldu SL, Mann MJ, Badani KK. Utilization and timing of blood transfusions following open and robot-assisted radical prostatectomy. J Endourol. 2014;28(12):1418-23. https://doi.org/10.1089/end.2014.0225 PMid:25333318 DOI: https://doi.org/10.1089/end.2014.0225

Agarwal PK, Sammon J, Bhandari A, Dabaja A, Diaz M, Dusik-Fenton S, et al. Safety profile of robot-assisted radical prostatectomy: A standardized report of complications in 3317 patients. Eur Urol. 2011;59(5):684-98. https://doi.org/10.1016/j.eururo.2011.01.045 PMid:21324583 DOI: https://doi.org/10.1016/j.eururo.2011.01.045

Reeves F, Preece P, Kapoor J, Everaerts W, Murphy DG, Corcoran NM, et al. Preservation of the neurovascular bundles is associated with improved time to continence after radical prostatectomy but not long-term continence rates: Results of a systematic review and meta-analysis. Eur Urol. 2015;68(4):692-704. https://doi.org/10.1016/j.eururo.2014.10.020 PMid:25454614 DOI: https://doi.org/10.1016/j.eururo.2014.10.020

Li X, Zhang H, Jia Z, Wang Y, Song Y, Liao L, et al. Urinary continence outcomes of four years of follow-up and predictors of early and late urinary continence in patients undergoing robot-assisted radical prostatectomy. BMC Urol. 2020;20(1):29. https://doi.org/10.1186/s12894-020-00601-w PMid:32188426 DOI: https://doi.org/10.1186/s12894-020-00601-w

Xylinas E, Durand X, Ploussard G, Campeggi A, Allory Y, Vordos D, et al. Evaluation of combined oncologic and functional outcomes after robotic-assisted laparoscopic extraperitoneal radical prostatectomy: Trifecta rate of achieving continence, potency and cancer control. Urol Oncol. 2013;31(1):99-103. https://doi.org/10.1016/s1569-9056(11)60873-7 PMid:21719321 DOI: https://doi.org/10.1016/S1569-9056(11)60873-7

Ficarra V, Novara G, Rosen RC, Artibani W, Carroll PR, Costello A, et al. Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy. Eur Urol. 2012;62(3):405-17. https://doi.org/10.1016/j.eururo.2012.05.045 PMid:22749852 DOI: https://doi.org/10.1016/j.eururo.2012.05.045

Brede C, Angermeier K, Wood H. Continence outcomes after treatment of recalcitrant postprostatectomy bladder neck contracture and review of the literature. Urology. 2014;83(3):648-52. https://doi.org/10.1016/j.urology.2013.10.042 PMid:24365088 DOI: https://doi.org/10.1016/j.urology.2013.10.042

Tyritzis SI, Katafigiotis I, Constantinides CA. All you need to know about urethrovesical anastomotic urinary leakage following radical prostatectomy. J Urol. 2012;188(2):369-76. https://doi.org/10.1016/j.juro.2012.03.126 PMid:22698622 DOI: https://doi.org/10.1016/j.juro.2012.03.126

Politano VA, Leadbetter WF. An operative technique for the correction of vesicoureteral reflux. J Urol. 1958;79(6):932-41. https://doi.org/10.1016/s0022-5347(17)66369-9 PMid:13539988 DOI: https://doi.org/10.1016/S0022-5347(17)66369-9

Pucheril D, Campbell L, Bauer RM, Montorsi F, Sammon JD, Schlomm T. A clinician’s guide to avoiding and managing common complications during and after robot-assisted laparoscopic radical prostatectomy. Eur Urol Focus. 2016;2(1):30-48. https://doi.org/10.1016/j.euf.2016.03.013 PMid:28723448 DOI: https://doi.org/10.1016/j.euf.2016.03.013

Coelho RF, Palmer KJ, Rocco B, Moniz RR, Chauhan S, Orvieto MA, et al. Early complication rates in a single-surgeon series of 2500 robotic-assisted radical prostatectomies: Report applying a standardized grading system. Eur Urol. 2010;57(6):945-52. https://doi.org/10.1016/j.eururo.2010.02.001 PMid:20181424 DOI: https://doi.org/10.1016/j.eururo.2010.02.001

Beck S, Skarecky D, Osann K, Juarez R, Ahlering TE. Transverse versus vertical camera port incision in robotic radical prostatectomy: Effect on incisional hernias and cosmesis. Urology. 2011;78(3):586-90. https://doi.org/10.1016/j.urology.2011.03.067 PMid:21741689 DOI: https://doi.org/10.1016/j.urology.2011.03.067

Novara G, Ficarra V, Mocellin S, Ahlering TE, Carroll PR, Graefen M, et al. Systematic review and meta-analysis of studies reporting oncologic outcome after robot-assisted radical prostatectomy. Eur Urol. 2012;62(3):382-404. https://doi.org/10.1016/j.eururo.2012.11.026 PMid:22749851 DOI: https://doi.org/10.1016/j.eururo.2012.11.026

Artibani W, Porcaro AB, De Marco V, Cerruto MA, Siracusano S. Management of biochemical recurrence after primary curative treatment for prostate cancer: A review. Urol Int. 2018;100(3):251-62. https://doi.org/10.1159/000481438 PMid:29161715 DOI: https://doi.org/10.1159/000481438

Bentas W, Wolfram M, Jones J, Brautigam R, Kramer W, Binder J. Robotic technology and the translation of open radical prostatectomy to laparoscopy: The early Frankfurt experience with robotic radical prostatectomy and one year follow-up. Eur Urol. 2003;44(2):175-81. https://doi.org/10.1016/s0302-2838(03)00256-2 PMid:12875935 DOI: https://doi.org/10.1016/S0302-2838(03)00256-2

Weiner AB, Murthy P, Richards KA, Patel SG, Eggener SE. Population based analysis of incidence and predictors of open conversion during minimally invasive radical prostatectomy. J Urol. 2015;193(3):826-31. https://doi.org/10.1016/j.juro.2014.09.113 PMid:25632850 DOI: https://doi.org/10.1016/j.juro.2014.09.113

Skarecky DW. Robotic-assisted radical prostatectomy after the first decade: Surgical evolution or new paradigm. ISRN Urol. 2013;2013:157379. https://doi.org/10.1155/2013/157379 PMid:23691367 DOI: https://doi.org/10.1155/2013/157379

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Published

2021-06-04

How to Cite

1.
Zaghloul A, Abdelbary A, Fergany A, Aboulkassem H, Fadlalla WM. Robotic Radical Prostatectomy at the Egyptian National Cancer Institute: Overcoming the Challenges in the Initial Case Series. Open Access Maced J Med Sci [Internet]. 2021 Jun. 4 [cited 2024 Apr. 30];9(B):367-72. Available from: https://oamjms.eu/index.php/mjms/article/view/6107

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