A concept of Fluid Integrated Circuit (FIC) was introduced which was developed as a particle handling device especially suitable for handling of bio-materials. This device handles particulate materials in a two dimensional micro channel constructed on a substrate using fluid and electrophoretic interactions. As concrete examples, cell fusion device and particle detecting device were shown. A pearl chain of one to one cell pair was easily formed in the cell fusion device. In the particle detecting device, particle detecting and size measurement were performed using the principle of coulter counter. Also a basic study on the integration of these unit components into a single device was described.