中华医学超声杂志

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超声法合成3,4-二甲氧基-4'-羟基查尔酮

杨洁1,李立忠1,申凤善2,李香丹1*   

  1. (1.中南民族大学化学与材料科学学院 武汉 430074；2.延边大学理学院 延吉 133002)
  • 收稿日期:2011-09-01 修回日期:2011-11-30 出版日期:2012-06-10 发布日期:2012-06-10
  • 通讯作者: 李香丹,教授; Tel/Fax:027-67842752; E-mail:xiangdanli@yahoo.com.cn; 研究方向：功能高分子材料
  • 基金资助:
    湖北省自然科学基金资助项目(2008CDB25)

Synthesis of 3, 4-Dimethoxy-4’-hydroxychalcone by ultrasound

YANG Jie1, LI Lizhong1, SHEN Fengshan2, LI Xiangdan1*   

  1. (1.College of Chemistry and Materials Science,South-Central University for Nationalities,Wuhan 430074,China;
    2.College of Science,Yanbian University,Yanji 133400,China)
  • Received:2011-09-01 Revised:2011-11-30 Published:2012-06-10 Online:2012-06-10
  • Contact: LI

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1357

被引次数

13 | 3

摘要： 以3,4-二甲氧基-苯甲醛和对羟基苯乙酮为原料，无水乙醇为溶剂，HCl气体为催化剂，在超声作用下，经Claisen-Schmidt缩合反应合成了3,4-二甲氧基-4′-羟基查尔酮。 产物结构经IR和1H NMR进行了表征，在2种原料摩尔比1∶1投料比条件下，优化的合成条件为超声输出功率240 W,反应温度30 ℃，反应时间20 min，产率达到92.1%，比传统方法反应时间短、操作简便、产率高。

关键词: 二甲氧基羟基查尔酮, 超声波, 合成

Abstract: 3,4-Dimethoxy-4′-hydroxychalcone was synthesized by the Claisen-Schmidt condensation using 3,4-dimethoxybenzaldehyde and 4′-hydroxyacetophenone as reagents with ultrasonic radiation and dry HCl(g) as catalyst. The structure of the product was confirmed by IR and 1H NMR. The optimized synthesis conditions were to use anhydrous ethanol as the solvent, reaction temperature of 30 ℃, ultrasonic radiation of 240 W, and radiation time of 20 min. A yield of 92.1% was obtained for the reaction with 1∶1 stoichiometric ratio for the starting materials. Compared with previous method in the literature, the present procedure requires a shorter reaction time, and has easier work-up and higher yield.

Key words: dimethoxyhydroxy chalcone, ultrasound, synthesis

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