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Year 2018, Volume: 10 Issue: 2, 766 - 775, 24.05.2018
https://doi.org/10.37212/jcnos.426634

Abstract

References

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Serum BDNF levels in suicide attempters related to psychosocial stressors: A comparative study with depression. Neuropsychobiology 56, 93–97. Dias, B.G., Banerjee, S.B., Duman, R.S., Vaidya, V.A. (2003). Differential regulation of Brain Derived Neurotrophic Factor transcripts by antidepressant treatments in the adult rat brain. Neuropharmacology 45, 553–563. Duman, R.S. (1997). A molecular and cellular theory of depression. Arch. Gen. Psychiatry 54, 597. Duman, R.S. (2004). Role of neurotrophic factors in the etiology and treatment of mood disorders. NeuroMolecular Med. 5, 011–026. Dwivedi, Y., Rizavi, H.S., Conley, R.R., Roberts, R.C., Tamminga, C.A., Pandey, G.N. (2003). Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch. Gen. Psychiatry 60, 804–815. Ernfors, P., Bramham, C.R. (2003). The coupling of a trkB tyrosine residue to LTP. Trends Neurosci. 26, 171–173. Gittos, M.W., Papp, M. (2001). 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Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats

Year 2018, Volume: 10 Issue: 2, 766 - 775, 24.05.2018
https://doi.org/10.37212/jcnos.426634

Abstract

Although antidepressant drugs have been used for approximately 60 years, very little is known about their effect mechanism. Structural abnormalities, particularly in the hippocampus, are observed in brain structures of depressed patients. The correction of these abnormalities with treatment suggests that major depressive disorders may be associated with a decrease in cellular elasticity and structural plasticity, and antidepressant treatments may provide benefits by treating these disorders. In this study, we aimed to investigate the effect of venlafaxine treatment on the brain-derived neurotrophic factor (BDNF) and BDNF levels in the hippocampus of depression-induced rats by using the chronic mild stress (CMS) model. In this study, 30 eight-week-old, Wistar albino male rats were divided into three groups. The first group received venlafaxine (20 mg/kg) with CMS, the second group a placebo with CMS, and the third group only a placebo (n = 10) for four weeks. At the end of the four week period, BDNF levels in hippocampus tissues were measured. The measurements showed that the BDNF levels of the depressed group were significantly lower than those of the control group. In our study, the hippocampal BDNF levels of the venlafaxine administered group were similar to those of the control group and significantly higher than those of the depressed group. In conclusion, these findings show that the BDNF, which has an important function in neuroplasticity, plays a role in depression pathophysiology, and venlafaxine prevents the BDNF decrease observed in depression. This latter result supports the view that depression treatment prevents the long-term complications of the disorder.

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Details

Primary Language English
Journal Section Original Articles
Authors

Arif Demirdaş

İbrahim Eren This is me

Hilmi Demirin This is me

Onur Aktürk This is me

Hüseyin Vural This is me

Publication Date May 24, 2018
Published in Issue Year 2018 Volume: 10 Issue: 2

Cite

APA Demirdaş, A., Eren, İ., Demirin, H., Aktürk, O., et al. (2018). Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats. Journal of Cellular Neuroscience and Oxidative Stress, 10(2), 766-775. https://doi.org/10.37212/jcnos.426634
AMA Demirdaş A, Eren İ, Demirin H, Aktürk O, Vural H. Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats. J Cell Neurosci Oxid Stress. May 2018;10(2):766-775. doi:10.37212/jcnos.426634
Chicago Demirdaş, Arif, İbrahim Eren, Hilmi Demirin, Onur Aktürk, and Hüseyin Vural. “Effect of Venlafaxine on Hippocampal BDNF Levels in Depression-Induced Rats”. Journal of Cellular Neuroscience and Oxidative Stress 10, no. 2 (May 2018): 766-75. https://doi.org/10.37212/jcnos.426634.
EndNote Demirdaş A, Eren İ, Demirin H, Aktürk O, Vural H (May 1, 2018) Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats. Journal of Cellular Neuroscience and Oxidative Stress 10 2 766–775.
IEEE A. Demirdaş, İ. Eren, H. Demirin, O. Aktürk, and H. Vural, “Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats”, J Cell Neurosci Oxid Stress, vol. 10, no. 2, pp. 766–775, 2018, doi: 10.37212/jcnos.426634.
ISNAD Demirdaş, Arif et al. “Effect of Venlafaxine on Hippocampal BDNF Levels in Depression-Induced Rats”. Journal of Cellular Neuroscience and Oxidative Stress 10/2 (May 2018), 766-775. https://doi.org/10.37212/jcnos.426634.
JAMA Demirdaş A, Eren İ, Demirin H, Aktürk O, Vural H. Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats. J Cell Neurosci Oxid Stress. 2018;10:766–775.
MLA Demirdaş, Arif et al. “Effect of Venlafaxine on Hippocampal BDNF Levels in Depression-Induced Rats”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 10, no. 2, 2018, pp. 766-75, doi:10.37212/jcnos.426634.
Vancouver Demirdaş A, Eren İ, Demirin H, Aktürk O, Vural H. Effect of venlafaxine on hippocampal BDNF levels in depression-induced rats. J Cell Neurosci Oxid Stress. 2018;10(2):766-75.