Epidemiology of chronic inducible urticaria in Moscow

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Abstract

BACKGROUND: Chronic inducible urticaria is a group of diseases that is characterized by the development of wheals, angioedema, or both in response to specific triggers for ≥6 weeks. According to global scientific international literature, the occurrence of chronic inducible urticaria is 0.5% in the general population and approximately 20%−30% in all chronic urticarias. The prevalence of chronic inducible urticaria has no statistical data in the Russian Federation.

AIM: This study aimed to evaluate the region-specific epidemiology of different forms of chronic inducible urticaria.

MATERIALS AND METHODS: The analysis is based on the number of unique cases extracted from the medical care records in the adults’ segment of the digital platform United medical information and analytical system (UMIAS) (outpatient forms) in Moscow from 2017 to 2021, including keyword search.

RESULTS: This study indicated that the prevalence of chronic inducible urticaria in Moscow is correlated with published global epidemiological data. Among patients with chronic inducible urticarial, females predominate (74.2%), and the median age was 43.8 years (37 years in males and 46.4 in females). The most common form in all verified cases of chronic inducible urticaria is symptomatic dermographism (11.12%), followed by contact urticaria (5.36%), cholinergic urticaria (2.28%), cold urticaria (1.92%), delayed pressure urticaria (0.36%), vibratory urticaria (0.11%), aquagenic urticaria (0.1%), and heat urticaria (0.08%). Chronic inducible urticaria rates in Moscow are high, which increase as in global practice. This research has limitations, including the lack of ubiquitous implementation of standard protocols of provocation testing in outpatient units and the low percentage of using validated questionnaires in the routine management of patients with chronic inducible urticaria.

CONCLUSIONS: Further studies dedicated to this topic are greatly necessary to answer a wide spectrum of questions, including the diagnosis process and evaluation of the severity of chronic inducible urticaria, comorbid conditions, and optimization of the treatment protocols adapted for the particular phenotype.

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About the authors

Daria S. Fomina

City Clinical Hospital No. 52; First Sechenov Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: daria_fomina@mail.ru
ORCID iD: 0000-0002-5083-6637
SPIN-code: 3023-4538

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, Moscow; Moscow

Natalya P. Maltseva

City Clinical Hospital No. 52

Email: filippova-nataly@mail.ru
ORCID iD: 0000-0002-4022-3570
SPIN-code: 2588-5718

MD

Russian Federation, Moscow

Sofia A. Serdotetskova

City Clinical Hospital No. 52

Email: darklynx813@gmail.com
ORCID iD: 0000-0001-8472-1152
SPIN-code: 6644-6715

MD

Russian Federation, Moscow

Inna V. Danilycheva

National Research Center ― Institute of Immunology Federal Medical-Biological Agency of Russia

Email: ivdanilycheva@mail.ru
ORCID iD: 0000-0002-8279-2173
SPIN-code: 4547-3948

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Marina S. Lebedkina

City Clinical Hospital No. 52

Email: marina.ivanova0808@yandex.ru
ORCID iD: 0000-0002-9545-4720
SPIN-code: 1857-8154

MD

Russian Federation, Moscow

Valeriya I. Mikhaylova

City Clinical Hospital No. 52

Email: lera1208@list.ru
ORCID iD: 0000-0003-0921-9212
SPIN-code: 2841-9652

MD

Russian Federation, Moscow

Elena V. Kovalkova

City Clinical Hospital No. 52

Email: kovalkova@ya.ru
ORCID iD: 0000-0002-1212-3767
SPIN-code: 3078-0976

MD

Russian Federation, Moscow

Nikita S. Chikunov

Moscow Center for Innovative Technologies in Healthcare

Email: artlicasio@gmail.com
ORCID iD: 0000-0002-0643-9423

MD

Russian Federation, Moscow

Alexander V. Karaulov

First Sechenov Moscow State Medical University (Sechenov University)

Email: drkaraulov@mail.ru
ORCID iD: 0000-0002-1930-5424
SPIN-code: 4122-5565

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Mariana A. Lysenko

City Clinical Hospital No. 52

Email: gkb52@zdrav.mos.ru
ORCID iD: 0000-0001-6010-7975
SPIN-code: 3887-6250

MD, Dr. Sci. (Med.)

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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2. Fig. 1. Correlation of the incidence of different chronic inducible urticaria types (in %).

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3. Fig. 2. Incidence of atopic diseases in patients with chronic inducible urticaria.

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4. Fig. 3. Incidence of comorbidities in patients with chronic inducible urticaria.Note: GIT: gastrointestinal tract; ENT: otorhinolaryngological (ear, nose, throat) diseases.

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5. Fig. 4. Increase in the incidence of outpatient visits by patients with cholinergic urticaria, cold urticaria, and dermographic urticaria.

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6. Fig. 5. Increase in the incidence of outpatient visits by patients with delayed pressure urticaria.

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