Abstract
Vitamin D is categorized as a fat‐soluble vitamin that has a significant impact on the metabolism of calcium, the maintenance of appropriate calcium balance and the formation of bones. Recent investigations have indicated that vitamin D has immunomodulatory and antibacterial properties. Vitamin D plays a crucial role in the effective functioning of the innate immune system by stimulating the production of antimicrobial peptides in epithelial cells, neutrophils and macrophages. To find the relationship between serums 25‐OH Vitamin D Levels in Term Neonates with Early Onset Sepsis in and to determine the possible association between neonatal 25‐OH vitamin D levels and early onset sepsis in term neonates a Tertiary Care Hospital. The study was a descriptive epidemiological investigation conducted in a hospital setting. It utilised a cross‐sectional design and involved two groups, namely cases and controls, for the purpose of comparison. The study group comprised of full‐term newborns who exhibited clinical and laboratory indications of early onset sepsis infection and were admitted to the Special Newborn Care Unit (SNCU) within the first three days after birth. These newborns had a gestational age of more than 37 weeks. The study was carried out in the Department of Paediatrics, Burdwan Medical College and Hospital, from October 2021 to September 2022. There is a clear and notable correlation between levels of Vitamin D and different types of white blood cells. The data suggests that persons who lack sufficient Vitamin D are more prone to experiencing leucocytosis, whereas those who have an adequate amount of Vitamin D are less likely to develop this illness. This is corroborated by the computed p‐value of 0.008*, indicating a statistically significant correlation. Moreover, a significant proportion of persons (38.60%) who have a deficiency are classified as having leucocytosis, in contrast to those with insufficiency (64.90%) and sufficiency (69.20%). These findings emphasise the possible influence of Vitamin D levels on the number of leukocytes, indicating the need for more investigation into the processes that explain this connection and its clinical significance. The conclusions can be inferred from the data and interpretation of the present study, as reported and discussed in the previous sections. This study found that term newborns with early‐onset sepsis (EOS) had significantly lower levels of neonatal vitamin D compared to healthy control infants who did not develop sepsis.
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