中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (11): 817-820.doi: 10.35541/cjd.20190234

• 论著 • 上一篇    下一篇

D2-40和Prox1在弥漫性躯体性血管角化瘤及匐行性血管瘤中的表达差异

顾安康    陈凤鸣    王雷   

  1. 空军军医大学第一附属医院皮肤科，西安  710032
    顾安康现在天津市中医药研究院附属医院病理科  300120

  • 收稿日期:2019-01-17 修回日期:2019-08-12 发布日期:2019-11-04
  • 通讯作者: 王雷 E-mail:wangleidermatology@qq.com

Difference in expression of lymphatic markers D2-40 and Prox1 between angiokeratoma corporis diffusum and angioma serpiginosum

Gu Ankang, Chen Fengming, Wang Lei   

  1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, China
    Gu Ankang is working on the Department of Pathology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
  • Received:2019-01-17 Revised:2019-08-12 Published:2019-11-04
  • Contact: Wang Lei E-mail:wangleidermatology@qq.com

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摘要： 【摘要】 目的 探讨淋巴管标记在弥漫性躯体性血管角化瘤（ACD）及匐行性血管瘤（AS）鉴别诊断中的意义。方法 回顾性分析2006—2017年西京皮肤医院确诊的9例ACD及6例AS患者的临床及组织病理学特点。对所有病例皮损均行CD31、D2-40及 Prox1染色。结果 9例ACD患者的异常脉管CD31呈弱阳性或阴性；ACD皮损异常管腔内皮细胞4例D2-40局灶阳性，5例D2-40阴性，9例Prox1阳性。6例AS患者增生的小血管内皮CD31 阳性，而D2-40和Prox1均阴性。结论 少数ACD及AS患者的临床特征有相似性，淋巴管标记在二者的鉴别诊断中具有明确的意义。

关键词: 血管瘤； 淋巴管瘤； 抗原, CD31； 诊断, 鉴别； 弥漫性躯体性血管角化瘤； D2-40； Prox1

Abstract: 【Abstract】 Objective To investigate the significance of lymphatic markers in the differential diagnosis of angiokeratoma corporis diffusum （ACD） and angioma serpiginosum （AS）. Methods Totally, 9 patients with ACD and 6 with AS were enrolled from Department of Dermatology, Xijing Hospital between 2006 and 2017, and their clinical and histopathological features were retrospectively analyzed. Skin sections from all the patients were stained for CD31, D2-40 and Prox1. Results In the 9 patients with ACD, abnormal vessels were weakly positive or negative for CD31, and positive for Prox1. Endothelial cells in abnormal vessels were locally positive for D2-40 in 4 patients with ACD, but negative for D2-40 in the other 5 patients. In the 6 patients with AS, the endothelia of hyperplastic small vessels were positive for CD31, but negative for D2-40 and Prox1. Conclusion The clinical features of a few patients with ACD are similar to those of patients with AS, and lymphatic markers have definite significance in the differential diagnosis of the two diseases.

Key words: Hemangioma, Lymphangioma, Antigens, CD31, Diagnosis, differential, Angiokeratoma corporis diffusum, D2-40, Prox1